Table 2: The diversity of MDDR Dataset activity class [19] sorted in descending where the homogeneity of classes decreases.

Activity Class	Pairwise Similarity (Mean)
Renin	0.290	Homogenous
AT1	0.229
HIVP	0.198
Thrombin	0.180
SubP	0.149
5HT3	0.140
5HT Reuptake	0.122
D2	0.138
5HT1A	0.133
PKC	0.120
COX	0.108	Heterogeneous