|
NRTI Only |
Combination with |
Combination with |
Combination with PI |
Total |
p |
|
(n = 233) |
NNRTI (n = 1094) |
PI (n = 990) |
Plus NNRTI (n = 41) |
(n = 2358) |
| Age > 45 years male, |
33 (14.2%) |
244 (22.3%) |
142 (14.4%) |
7 (17.1%) |
426 (18.1%) |
0.0001 |
| > 55 female, |
[10.0%,19.3%] |
[19.9%,24.9%] |
[12.2%,16.7%] |
[7.2%,32.1%] |
[16.5%,19.7%] |
| (%) [95%CI] &
|
|
|
|
|
|
| Body mass index |
24.1 |
23.82 |
23.56 |
23.56 |
23.82 |
0.0700 |
| median [IQR] |
[22.28,26.22] |
[21.81,25.59] |
[21.52,25.56] |
[21.05,25.95] |
[21.75,25.67] |
| Body mass index > 30 kg/m2
|
9 (3.9%) |
29 (2.7%) |
41 (4.1%) |
3 (7.3%) |
82 (3.5%) |
0.1428 |
| [95%CI] |
[1.8%,7.2%] |
[1.8%,3.8%] |
[3.0%,5.6%] |
[1.5%,19.9%] |
[2.8%,4.3%] |
| Current smoker, |
146 (62.7%) |
588 (53.7%) |
641 (64.7%) |
22 (53.7%) |
1397 (59.2%) |
<0.0001 |
| (%) [95%CI] |
[56.1%,68.9%] |
[50.7%,56.7%] |
[61.7%,67.7%] |
[37.4%,69.3%] |
[57.2%,61.2%] |
| Family story of CVD |
30 (12.9%) |
157 (14.4%) |
116 (11.7%) |
3 (7.3%) |
306 (13.0%) |
0.2227 |
| (%) [95%CI] |
[8.9%,17.9%] |
[12.3%,16.6%] |
[9.8%,13.9%] |
[1.5%,19.9%] |
[11.6%,14.4%] |
| Previous CVD |
7 (3.0%) |
17 (1.6%) |
16 (1.6%) |
0 (0.0%) |
40 (1.7%) |
0.352 |
| (%) [95%CI] |
[1.2%,6.1%] |
[0.9%,2.5%] |
[0.9%,2.6%] |
[0.0%,7.0%] |
[1.2%,2.3%] |
| Hypertension |
50 (21.5%) |
272 (24.9%) |
212 (21.4%) |
5 (12.2%) |
539 (22.9%) |
0.0886 |
| (%) [95%CI] &
|
[16.4%,27.3%] |
[22.3%,27.5%] |
[18.9%,24.1%] |
[4.1%,26.2%] |
[21.2%,24.6%] |
| Diabetes mellitus, |
21 (9.0%) |
98 (9.0%) |
52 (5.3%) |
1 (2.4%) |
172 (7.3%) |
0.0046 |
| (%) [95%CI] |
[5.7%,13.4%] |
[7.3%,10.8%] |
[3.9%,6.8%] |
[0.1%,12.9%] |
[6.3%,8.4%] |
| Total cholesterol (mmol/l), |
4.56 |
4.97 |
4.82 |
5.85 |
4.87 |
<0.0001 |
| median [IQR] |
[3.83,5.13] |
[4.20,5.78] |
[4.12,5.65] |
[4.61,6.94] |
[4.12,5.67] |
| Total cholesterol > 6.2 mmol/l, |
11 (4.7%) |
172 (15.7%) |
145 (14.6%) |
18 (43.9%) |
346 (14.7%) |
<0.0001 |
| (%) [95%CI] |
[2.4%,8.3%] |
[13.6%,18.0%] |
[12.5%,17.0%] |
[28.5%,60.3%] |
[13.3%,16.2%] |
| HDL cholesterol (mmol/l), |
1.09 |
1.27 |
1.17 |
1.19 |
1.19 |
<0.0001 |
| median [IQR] |
[0.88,1.32] |
[1.01,1.58] |
[0.93,1.45] |
[1.04,1.55] |
[0.96,1.48] |
| HDL cholesterol < 0.9 mmol/l, |
60 (25.8%) |
157 (14.4%) |
216 (21.8%) |
6 (14.6%) |
439 (18.6%) |
<0.0001 |
| (%) [95%CI] |
[20.3%,31.9%] |
[12.3%,16.6%] |
[19.3%,24.5%] |
[5.6%,29.2%] |
[17.1%,20.2%] |
|
TC/HDL ratio |
4.2 |
3.87 |
4.17 |
4.72 |
4.05 |
<0.0001 |
| [3.13,5.19] |
[3.07,4.95] |
[3.18,5.30] |
[3.68,5.77] |
[3.13,5.13] |
| LDL cholesterol (mmol/l) |
2.51 |
2.9 |
2.75 |
3.44 |
2.81 |
<0.0001 |
| median [IQR] &
|
[1.94,3.21] |
[2.23,3.63] |
[2.05,3.55] |
[2.38,4.35] |
[2.10,3.57] |
| LDL cholesterol > 4.14 mmol/l, |
11 (4.8%) |
142 (13.0%) |
122 (12.4%) |
12 (29.3%) |
287 (12.2%) |
<0.0001 |
| (%) [95%CI] &
|
[2.4%,8.4%] |
[11.1%,15.2%] |
[10.4%,14.6%] |
[16.1%,45.5%] |
[10.9%,13.6%] |
| Triglycerides (mmol/l), |
4.56 |
4.97 |
4.82 |
5.85 |
4.87 |
<0.0001 |
| median [IQR] |
[3.83,5.13] |
[4.20,5.78] |
[4.12,5.65] |
[4.61,6.94] |
[4.12,5.67] |
| Triglycerides > 2.3 mmol/l, |
58 (24.9%) |
239 (21.8%) |
294 (29.7%) |
20 (48.8%) |
611 (25.9%) |
<0.0001 |
| (%) [95%CI] |
[19.5%,31.0%] |
[19.4%,24.4%] |
[26.9%,32.7%] |
[32.9%,64.9%] |
[24.2%,27.7%] |
| Lipodystrophy, |
41 (17.6%) |
200 (18.3%) |
168 (17.0%) |
11 (26.8%) |
420 (17.8%) |
0.4027 |
| (%) [95%CI] |
[12.9%,23.1%] |
[16.0%,20.7%] |
[14.7%,19.5%] |
[14.2%,42.9%] |
[16.3%,19.4%] |
Descriptive statistics are n (%) [95%CI] for qualitative, and median [IQR] for qualitative variables. NRTI = nucleoside reverse transcriptase inhibitors, NNRTI = non-nucleoside reverse transcriptase inhibitors, PI = protease inhibitors, CVD = cardiovascular disease, LDL = low density lipoprotein, HDL = high density lipoprotein, TC = total cholesterol.
&Percentage of missingness < 1%; null percentage for the rest of variables.