Fig. (3) Schematic diagram showing the suggested initial events occurring in the foreskin during HIV (type-1) transmission. (Left) In inner foreskin, while cell-free HIV-1 and lightly HIV-1 infected cells unlikely to initiate and disseminate infection through inner foreskin, the cells infected heavily with virus easily infects the target LC cells in epidermis and disseminate infection at dermis through DCs and T cells (1-6). (Right) In outer foreskin, both newly budded HIV-1 particles and cell-free HIV-1 virions remain trapped within the thick layer of keratin at OFS limiting virus entry into the epidermis and infection being disseminated (7-9). (Reproduced with permission) [22].