Fig. (2) RANK:Fc-treated TNF-Tg mice have reduced synovial inflammation in joints.Ten-week-old TNF-Tg were treated with RANK:Fc or PBS for 2 months. (A) Representatives of H&E-stained sections from a PBS-treated TNF-Tg and a RANK:Fc-treated TNF-Tg mouse (2X magnification). The area of synovial tissue was indicated by black arrow heads. (B) Histomorphometric analyses of knee joint sections and (C) serum human TNF transgene concentration were measured as described in Fig. (1). Values are presented as the mean plus SEM of 8 mice per group. *p< 0.05 vs PBS-treated TNF-Tg mice.