| Disease | Role of Dendritic Cells |
|---|---|
| Rheumatoid arthritis | mDCs present citrullinated collagens and fibrin to autoreactive T cells and drive autoantibody and TNF-a production |
| pDCs produce IFN-a in response to nucleic acid sequences complexed to rheumatoid factor | |
| Systemic lupus erythematosus | pDCs produce IFN-a in response to nucleic acid-containing immune complexes which signal through TLR7 and TLR9 |
| pDC-produced IFNs drive autoantibody production | |
| Multiple Sclerosis | mDCs present self-antigens of myelin to pathogenic T cells |
| Intra-cerebral DCs modulate encephalitogenic versus regulatory immune responses in CNS | |
| Psoriasis | pDCs in inflammed skin secrete IFN-a |
| Insulin-dependent diabetes mellitus | pDCs might be involved in IFN-a secretion in pancreas |
| Myositis and Polymyositis | mDCs are mainly found at the site of lesions |
| Dermatomyositis | Type I IFN producing pDCs are abundant |
| Sjogrens syndrome | pDCs in salivary glands might favour IFN-inducible genes |