Fig. (1) Procedure for direct bone marrow prolotherapy#1 Procaine, or other suitable numbing agent, is injected into the tibia to anesthetize the site of the bone marrow extraction. #2 An EZIO drill, is used to pierce the tibial bone for extraction of the bone marrow.#3 The bone marrow is drawn from the tibial bone. #4 The entire bone marrow aspirate is then injected directly into the knee joint or other injury site. #5 Following the bone marrow treatment, standard prolotherapy is performed around the entire joint to accelerate the growth and repair of the surrounding ligaments and tendons.*Steps 4 and 5 are intechangeable.