The Open Anesthesia Journal


Formerly: The Open Anesthesiology Journal

ISSN: 2589-6458 ― Volume 13, 2019
RESEARCH ARTICLE

Preemptive Alveolar Recruitment Maneuver Followed by PEEP in Obese Patients Undergoing Laparoscopic Gastric Banding. Does it make a Difference? A Randomized Controlled Clinical Study



Sherif A. Elokda*, Hanan M. Farag
Department of Anesthesia, Intensive Care, and Pain Management, Ain Shams University, Cairo, Egypt

Abstract

Background:

Impaired respiratory functions during general anesthesia are commonly caused by lung atelectasis more in morbidly obese patients. This occurs more frequently with laparoscopic surgery due to trendelenburg position and pneumoperitoneum. Preemptive recruitment maneuver + PEEP results in the prevention of these changes.

Aim:

To quantitate the effects of RM and PEEP on intraoperative hypoxemia and respiratory mechanics during laparoscopic gastric banding in obese patients.

Study Design:

A randomized, double-blinded, controlled study.

Method and Materials:

Fifty adults ASA I-II, BMI (40-50 kg/m2) for elective laparoscopic gastric banding were randomized into, groups C, and RM, 25 patients each. Group C patients received standard ventilation, VT 6 ml/kg, I: E ratio 1: 2 PEEP 5 cm H2O, and respiratory rate 10-12 breaths/ min. RM patients received standard ventilation with one alveolar recruitment maneuver after mechanical ventilation with PEEP of 15 cm H2O till the end of the surgery. Heart rate, mean blood pressure, respiratory mechanical parameters: peak airway pressure, plateau pressure and end-expiratory lung volume, PaO2, PaO2/FiO2 and (SpO2) were assessed.

Results:

PaO2 and PaO2/FiO2 ratio increased significantly in the RM group after RM from T2 (before pneumoperitoneum) to T6 (end of surgery) compared with group C (P < 0.001). Peak and plateau airway pressures increased significantly in group C from T2 till T5 (60 min after pneumoperitoneum) compared with the RM group (P < 0.001). End-expiratory lung volume increased significantly in the RM group after RM compared with group C (P<0.001).

Conclusion:

Preemptive RM with PEEP of 15 cm H2O was effective in preventing pneumoperitoneum-induced intraoperative hypoxemia and respiratory mechanics changes.

Keywords: Preemptive, Recruitment, Maneuver, Morbidly, Obese, Laparoscopic, Gastric, Banding.


Article Information


Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 31
Last Page: 39
Publisher Id: TOATJ-13-31
DOI: 10.2174/2589645801913010031

Article History:

Received Date: 14/1/2019
Revision Received Date: 10/03/2019
Acceptance Date: 11/04/2019
Electronic publication date: 30/04/2019
Collection year: 2019

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© 2019 Elokda and Farag.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at Department of Anesthesia, Intensive Care, and Pain Management, Ain Shams University, Cairo, Egypt;
E-mail: shelokda99@yahoo.com





1. INTRODUCTION

World Health Organization defined obesity as a Body Mass Index (BMI) above 30 kg/m2. The characteristic physiological changes induced by obesity such as decreased Functional Residual Capacity (FRC), increased demand for oxygen, decreased lung compliance, and altered ventilation-perfusion ratio make these patients prone to perioperative complications like atelectasis, hypoxia and hypercapnia [1Aldenkortt M, Lysakowski C, Elia N, Brochard L, Tramèr MR. Ventilation strategies in obese patients undergoing surgery: A quantitative systematic review and meta-analysis. Br J Anaesth 2012; 109(4): 493-502.[http://dx.doi.org/10.1093/bja/aes338] [PMID: 22976857] ].

Several clinical trials have tested different intra-operative ventilation strategies in these patients to re-inflate the collapsed lungs and optimize the oxygenation. These strategies include the application of Positive End Expiratory Pressure (PEEP) or Recruitment Maneuvers (RM) in the form of application of positive airway pressure to re-inflate the collapsed lung tissue [2Tusman G, Böhm SH, Vazquez de Anda GF, Do Campo JL, Lachmann B. ‘Alveolar recruitment strategy’ improves arterial oxygenation during general anaesthesia. Br J Anaesth 1999; 82(1): 8-13.[http://dx.doi.org/10.1093/bja/82.1.8] [PMID: 10325828] ].

End Expiratory Lung Volume (EELV) which is the functional residual capacity during mechanical ventilation has been found to be a sensitive indicator than oxygenation for PEEP- induced alveolar recruitment [3Rylander C, Högman M, Perchiazzi G, Magnusson A, Hedenstierna G. Functional residual capacity and respiratory mechanics as indicators of aeration and collapse in experimental lung injury. Anesth Analg 2004; 98(3): 782-9.[http://dx.doi.org/10.1213/01.ANE.0000096261.89531.90] [PMID: 14 980937] ]. No well-known effective ventilation protocol has been established for obese patients undergoing the laparoscopic procedure with general anesthesia. This ventilation strategy would be expected to optimize respiratory mechanics, gas exchange, and minimize the risk of postoperative respiratory complications.

Therefore, the rational stands behind this study were to quantitate the effects of preemptive alveolar recruitment maneuver followed by PEEP on intraoperative gas exchange, respiratory mechanics and hemodynamics for laparoscopic gastric banding in obese patients under general anesthesia. We hypothesized that RM followed immediately with PEEP could attenuate the intra-operative pneumoperitoneum-induced detrimental effects on gas exchange and respiratory mechanics.

2. PATIENTS AND METHODS

2.1. Study Groups

After obtaining the approval of our institutional ethics and research committee (FMASU R64/2018), written informed consent was taken from all patients. Fifty American Society of Anesthesiologist (ASA) physical status II-III patients scheduled for elective gastric banding were prospectively included in the current study, patients were enrolled into one of two randomized, double-blind, controlled study groups using a randomization schedule generated by computer and sealed opaque envelopes.

Patients were eligible for inclusion if they were; 20-50 years of age and had Body Mass Index (BMI) between 40 and 50 kg/m2. They were excluded if they had one of the following: previous lung surgery, chronic obstructive pulmonary disease, restrictive lung disease, bronchial asthma, home oxygen therapy, lung bullae, uncompensated cardiac disease (NYHA class III or IV), hemodynamic instability and increased intracranial pressure. In addition, any patient who developed hemodynamic instability (mean blood pressure < 60 mmHg) or desaturation (SpO2 < 90%) during the recruitment procedure was excluded from the study.

Patients were randomly divided into two groups, control group (group C, n = 25) and study RM group (group RM, n = 25) (Fig. 1). All patients were fasted at least 8 hrs before induction of anesthesia and were premeditated with granisetron 1 mg IV, ranitidine 50 mg IV and midazolam 2 mg IV before shifting to the operating theatre. Group C patients received the standard ventilation protocol immediately after intubation as the following; Volume Controlled Ventilation mode (VCV), with VT 6 ml/kg of Ideal Body Weight (IBW), inspiratory: Expiratory ratio 1: 2, Positive End Expiratory Pressure (PEEP) of 5 cm H2O, and respiratory rate 10-12 breaths/ min that was adjusted to keep End-Tidal Carbon Dioxide tension (ETCO2) between 35-45 mmHg. Patients in group RM received the standard ventilation protocol immediately after intubation with one alveolar recruitment maneuver, followed by PEEP of 15 cm H2O done as soon as the patient connected to mechanical ventilation till end of surgery and extubation. The recruitment was performed as soon as the patient was connected to mechanical ventilation and before positioning and initiation of pneumoperitoneum by application of continuous positive airway pressure 40 cm H2O for 45 seconds. This recruitment maneuver was followed immediately by PEEP of 15 cm H2O in the study group (group RM) that was kept constant throughout till the end of surgery and deflation of pneumoperitoneum. For safety, the peak inspiratory pressure of the ventilator was limited to 45 cm H2O. Engström Carestation ventilator (General electric, Helsinki, Finland) was used in this study. Many studies have been done to evaluate the accuracy, precision and reproducibility of measurements of EELV done by this ventilator [4Bikker IG, Scohy TV, Bakker J, Gommers D. Measurement of end-expiratory lung volume in intubated children without interruption of mechanical ventilation. Intensive Care Med 2009; 35(10): 1749-53.[http://dx.doi.org/10.1007/s00134-009-1579-0] [PMID: 19626312] -6Whalen FX, Gajic O, Thompson GB, et al. The effects of the alveolar recruitment maneuver and positive end-expiratory pressure on arterial oxygenation during laparoscopic bariatric surgery. Anesth Analg 2006; 102(1): 298-305.[http://dx.doi.org/10.1213/01.ane.0000183655.57275.7a] [PMID: 163 68847] ].

2.2. Anesthetic Technique

On arrival of the patient to the operating theatre and before induction of anesthesia, all standard monitors were applied including Heart Rate (HR), Electrocardiogram (ECG), oxygen saturation (SpO2), end-tidal CO2, arterial blood pressure (systolic (SBP), diastolic (DBP) & mean (MAP)) and temperature. Additionally, monitoring of neuromuscular blockade by Train of Four (TOF) and BIS electrodes (BIS QUATRO-BX13366, Aspect Medical Systems, Inc. Chicago, USA) were connected to the patient.For continuous blood pressure monitoring and frequent blood gas analysis, a radial artery catheter was inserted after induction of anesthesia. Preoxygenation with 100% oxygen face mask for 5 min was done for all patients and anesthetic management was standardized for all patients as follows.

Anesthesia was induced by intravenous remifentanil (1µg /kg) over 30-60 seconds, followed by propofol 2 mg/kg. Intubation was facilitated with succinylcholine (1 mg/kg) and cuffed 7-7.5 mm endotracheal tube (Portex, Inc., London, England) was inserted. Maintenance of anesthesia was carried out by continuous infusion of remifentanil (0.25µg/kg/min), propofol infusion (3-5 mg/kg/h) and inspired oxygen fraction of 0.5 mixed with air. Anesthesia was titrated to keep the 'BIS' value within the range 40-50. Muscle relaxation was monitored by 'TOF' every ten minutes, rocuronium infusion from 0.2-0.6 mg/kg/hr was given and adjusted to maintain 1-2 twitches on the 'TOF' stimulation. Lungs were mechanically ventilated to maintain normocapnia (EtCO2 35-45 mmHg). All surgical procedures were done by the same surgeon who was blind about the study.

All vital signs were continuously monitored and recorded regularly throughout the procedure till the end of the surgery and extubation. Anesthesia was given to all patients by a single anesthetist who was not involved in the study and requested to follow the study design. Ringer acetate solution was set at a rate of 10 ml/kg/hr as a baseline infusion in all groups to assure optimization of intravascular volume and hemodynamic stability. Additional solutions were infused if required.

Fig. (1)
Consort patient flowchart.


Pneumoperitoneum was generated by insufflating carbon dioxide into the abdomen with intra-abdominal pressure maintained at 12 cm H2O during the procedure. A bolus of normal saline 0.9% 250 ml and/or incremental doses of vasopressor drugs (ephedrine 5 mg or phenylephrine 50µg) was used for intraoperative hypotension (reduction in mean arterial blood pressure (MAP) > 25%). Discontinuation of all anesthetic agents and 100% oxygen ventilation were done at the end of surgical procedure. The residual effect of rocuronium was reversed with neostigmine in a dose of 40 µg/kg and atropine sulfate 20 µg/kg. Then after regaining patients’ spontaneous breathing, they were extubated and transferred to the Post Anesthesia Care Unit (PACU) for routine follow up. Postoperative analgesia was started with pethidine 50 mg IM every 8 hours paracetamol infusion 1 gm every 6 hours to keep Visual Analogue Scale (VAS) ≤ 4 . After fulfilling the recovery discharge criteria, patients were transferred to the ward. Chest X-ray was performed 2 hours postoperatively and 24 hours later to exclude any adverse effects of the recruitment maneuver.

2.3. Data for Assessment

  • Hemodynamic Parameters: Heart Rate (HR), Mean Blood Pressure (MAP).
  • Respiratory Mechanical Parameters: Peak Airway Pressure (Paw-peak), Plateau Pressure (Paw-plat) and End Expiratory Lung Volume (EELV).
  • Oxygenation Parameters: Partial Arterial Oxygen tension (PaO2), Partial pressure of arterial oxygen/ fraction of inspired oxygen ratio (mmHg) and Oxygen saturation (SaO2).

All these measurements were performed at the following time intervals; T1 (baseline) preoperatively, T2 before induction of pneumoperitoneum, T3 immediately after induction of pneumoperitoneum, T4 30 minutes after pneumoperitoneum, and T5 60 minutes after pneumoperitoneum & T6 following pneumoperitoneum deflation and at the end of surgery. EELV was measured by nitrogen (wash-out/ wash-in) using an automated module available on the ventilator.

The primary outcome for the current study was to evaluate the efficacy of preemptive alveolar recruitment maneuver on pneumoperitoneum induced intraoperative hypoxemia (PaO2) while the secondary outcome was to assure pulmonary and extra-pulmonary safety of this maneuver. The pulmonary safety was assessed by monitoring of intraoperative changes in respiratory mechanics, arterial blood gases and chest X-ray in the recovery room to detect hypoxia or pneumothorax if present while the extra-pulmonary safety was assessed by monitoring the vital signs for the presence of hypotension or any arrhythmia.

2.4. Statistical Analysis and Sample Size

The collected data were coded, tabulated, and statistically analyzed using IBM SPSS statistics (Statistical Package for Social Sciences) software version 18.0, IBM Corp., Chicago, USA, 2009.

Descriptive statistics was done for quantitative data as mean ± SD (standard deviation) for quantitative normally distributed data while it was done for qualitative data as number and percentage.

For quantitative variables inferential analyses were done using the Shapiro-Wilk test for normality testing, and for the independent groups, an independent t-test was used. Mean ± SD and the 95% Confidence Interval (CI) were calculated for the differences between groups. Chi-square test was used for inferential analyses of independent variables in terms of qualitative data with the difference between proportions. The level of significance taken at p-value < 0.050 was significant, otherwise it was considered non-significant. The p-value is a statistical measure for the probability that the results observed in a study could have occurred by chance.

3. RESULTS

Regarding patients' characteristics and operative data (Table 1) there was no significant difference between both groups in this study.

3.1. Arterial Oxygenation

This study documented that there was a significant reduction in PaO2 and PaO2/FiO2 ratio among patients in the control group (group C) throughout the procedure till the end of surgery and after deflation of pneumoperitoneum where they start to increase to reach baseline values. In contrast, both PaO2 and PaO2/FiO2 were significantly increased till the end of surgery and deflation of pneumoperitoneum (T6). These results demonstrated a significant difference between both groups regarding PaO2 and PaO2/FiO2 from T2 till the end of surgery and deflation of pneumoperitoneum (P < 0.05) (Figs. 2 and 3).

Regarding oxygen saturation, the results demonstrated that there were no significant differences between both study groups at all-time intervals (P> 0.05) (Fig. 4).

Table 1
Baseline characteristics.


Fig. (2)
Partial arterial oxygen tension (mmHg) between both study groups.


Fig. (3)
Partial arterial oxygen tension/Inspired oxygen fraction ratio (mmHg) between both study groups.


3.2. Respiratory Mechanical Parameters

Peak and plateau airway pressures were increased significantly in the group C after initiation of pneumoperitoneum at T3 and stayed high throughout the procedure till surgery end and deflation of pneumoperitoneum (T6) where both parameters declined to lower values. Meanwhile, there was a slight non-significant increase in both parameters among the patients in the RM group throughout the procedure that decreased to readings near the baseline values by the end of surgery and deflation of pneumoperitoneum. Peak and plateau airway pressures showed a significant difference between both groups starting from T2 throughout the procedure till surgery end and deflation of pneumoperitoneum T6 (P < 0.05) (Figs. 5 and 6).

Fig. (4)
Oxygen saturation (SaO2) in percentage (%) between both study groups.


Fig. (5)
Peak airway pressure (cm H2O) between both study groups.


Fig. (6)
Plateau airway pressure (cmH2O) between both study groups.


Regarding the End Expiratory Lung Volume (EELV), this study documented a dramatic decrease in EELV among the patients in the control group starting from T2 and continued low during the procedure till T5 then started to increase following pneumoperitoneum deflation at T6. On the other hand, patients in the RM group showed a significant increase in EELV after application of RM and PEEP then continued high till T4 after that declined but still higher than the baseline values at T5 and finally, increased again significantly after pneumoperitoneum deflation at T6. There was a statistically significant difference between both study groups regarding EELV (P < 0.05) (Fig. 7).

Fig. (7)
End expiratory lung volume (ml) between both study groups.


3.3. Hemodynamic Parameters

Both study groups demonstrated no significant difference in terms of Mean Arterial Blood Pressure (MAP), Heart Rate (HR), using unpaired t-test (P > 0.05).

3.4. Postoperative Complications

In terms of postoperative complications, there was no incidence of hypoxia, infection or pneumothorax in both study groups.

4. DISCUSSION

Data from our study demonstrated that Recruitment Maneuver (RM) application followed immediately with 15 cm H2O Positive End Expiratory Pressure (PEEP) before initiation of pneumoperitoneum in patients undergoing laparoscopic gastric banding was effective in improvement of intraoperative oxygenation and prevention of hypoxemia. Moreover, there were great improvements in respiratory mechanics without any harmful effects on patients’ hemodynamic parameters.

4.1. Oxygenation and Gas Exchange

This study documented that there was a marked increase in both PaO2 and PaO2/FiO2 among the patients in RM group with a significant difference when compared with patients in the control group (P < 0.05). This increase started after application of RM and before pneumoperitoneum initiation and continued high throughout the procedure.

Our results were in agreement with the results of other multiple randomized control studies that assessed the effects of using alveolar recruitment maneuver together with PEEP on intraoperative oxygenation, respiratory mechanics and postoperative complications. Regardless of the method used for the application of RM, positive results were achieved across these studies in terms of respiratory mechanics and oxygenation [7Valenza F, Vagginelli F, Tiby A, et al. Effects of the beach chair position, positive end-expiratory pressure, and pneumoperitoneum on respiratory function in morbidly obese patients during anesthesia and paralysis. Anesthesiology 2007; 107(5): 725-32.[http://dx.doi.org/10.1097/01.anes.0000287026.61782.a6] [PMID: 180 73547] -11Cinnella G, Grasso S, Spadaro S, et al. Effects of recruitment maneuver and positive end-expiratory pressure on respiratory mechanics and transpulmonary pressure during laparoscopic surgery. Anesthesiology 2013; 118(1): 114-22.[http://dx.doi.org/10.1097/ALN.0b013e3182746a10] [PMID: 2319 6259] ].

In contrast to our study, some other studies proved that application of PEEP alone was not effective in improving intraoperative oxygenation during laparoscopic abdominal surgeries [12Chalhoub V, Yazigi A, Sleilaty G, et al. Effect of vital capacity manoeuvres on arterial oxygenation in morbidly obese patients undergoing open bariatric surgery. Eur J Anaesthesiol 2007; 24(3): 283-8.[http://dx.doi.org/10.1017/S0265021506001529] [PMID: 17087847] , 13Futier E, Constantin JM, Pelosi P, et al. Intraoperative recruitment maneuver reverses detrimental pneumoperitoneum-induced respiratory effects in healthy weight and obese patients undergoing laparoscopy. Anesthesiology 2010; 113(6): 1310-9.[http://dx.doi.org/10.1097/ALN.0b013e3181fc640a] [PMID: 2106 8660] ]. Both groups showed no significant difference regarding peripheral oxygen saturation (P > 0.05) and this can be explained by the plateau of oxyhemoglobin dissociation curve near 100% saturation.

4.2. Respiratory Mechanics

Present study results showed an abrupt increase in both peak and plateau airway pressures among the patients in the control group with a significant difference when compared with patients in the RM group (P < 0.05). This elevation in both pressures started after positioning and before induction of pneumoperitoneum then, continued throughout the procedure till end of surgery and deflation of pneumoperitoneum. This can be explained by the application of PEEP after RM was successful in counterbalance the pneumoperitoneum-induced cranial shift of the diaphragm giving more space for lung expansion.

Our results were consistent with the results of the study done by Cinnella, et al. [11Cinnella G, Grasso S, Spadaro S, et al. Effects of recruitment maneuver and positive end-expiratory pressure on respiratory mechanics and transpulmonary pressure during laparoscopic surgery. Anesthesiology 2013; 118(1): 114-22.[http://dx.doi.org/10.1097/ALN.0b013e3182746a10] [PMID: 2319 6259] ] who studied the effects of Recruitment Maneuver (RM) and Positive End Expiratory Pressure (PEEP) on respiratory mechanics and transpulmonary pressure during laparoscopic surgery and documented that RM together with PEEP was able to reduce the pneumoperitoneum induced changes in respiratory mechanics.

Also, our results were supported by another study done by Futier E, et al. [13Futier E, Constantin JM, Pelosi P, et al. Intraoperative recruitment maneuver reverses detrimental pneumoperitoneum-induced respiratory effects in healthy weight and obese patients undergoing laparoscopy. Anesthesiology 2010; 113(6): 1310-9.[http://dx.doi.org/10.1097/ALN.0b013e3181fc640a] [PMID: 2106 8660] ] who concluded that application of 10 cmH2O PEEP combined with RM was successful in counteracting the detrimental effects of pneumoperitoneum in both healthy weight and obese patients undergoing laparoscopy.

In terms of End Expiratory Lung Volume (EELV), the present study demonstrated a dramatic increase in EELV among patients in RM group with a significant difference when compared with the control group patients (P < 0.05). This increase started before induction of pneumoperitoneum then, continued high till 30 minutes after that, there was a slight decrease that improved dramatically at the end of surgery and deflation of pneumoperitoneum.

Our results were consistent with those of Futier E, et al. [13Futier E, Constantin JM, Pelosi P, et al. Intraoperative recruitment maneuver reverses detrimental pneumoperitoneum-induced respiratory effects in healthy weight and obese patients undergoing laparoscopy. Anesthesiology 2010; 113(6): 1310-9.[http://dx.doi.org/10.1097/ALN.0b013e3181fc640a] [PMID: 2106 8660] ], who found that application of RM and PEEP of 10 cm H2O was associated with a greater increase in EELV compared with PEEP alone in both healthy weight and obese patients undergoing laparoscopy.

Moreover, Maisch S, et al. [14Maisch S, Reissmann H, Fuellekrug B, et al. Compliance and dead space fraction indicate an optimal level of positive end-expiratory pressure after recruitment in anesthetized patients. Anesth Analg 2008; 106(1): 175-81.[http://dx.doi.org/10.1213/01.ane.0000287684.74505.49] [PMID: 181 65575] ], reported that RM followed by high PEEP levels was necessary to increase EELV during laparoscopy.

4.3. Safety of the Recruitment Maneuver

The results of the current study showed no significant changes between both groups regarding Mean Arterial Blood Pressure (MAP) and Heart Rate (HR) (P > 0.05). This can be explained by optimization of intravascular volume load for our patients by crystalloid infusion. Our results were in agreement with those of Bohm, et al. [15Bohm SH, Thamm OC, von Sandersleben A, et al. Alveolar recruitment strategy and high positive end-expiratory pressure levels do not affect hemodynamics in morbidly obese intravascular volume-loaded patients. Anesth Analg 2009; 109(1): 160-3.[http://dx.doi.org/10.1213/ane.0b013e3181a801a3] [PMID: 19535706] ], who confirmed the hemodynamic safety of RM and application of PEEP in intravascular volume loaded patients.

In contrast, one study documented a significantly higher dose of vasopressor used for patients in the recruitment maneuver group compared with the control group [6Whalen FX, Gajic O, Thompson GB, et al. The effects of the alveolar recruitment maneuver and positive end-expiratory pressure on arterial oxygenation during laparoscopic bariatric surgery. Anesth Analg 2006; 102(1): 298-305.[http://dx.doi.org/10.1213/01.ane.0000183655.57275.7a] [PMID: 163 68847] ].

There was no incidence of hypoxia, infection or pneumothorax in both study groups. Our results were in agreement with the results of other many studies that documented the safety of RM and PEEP and they didn’t report any case of barotrauma [7Valenza F, Vagginelli F, Tiby A, et al. Effects of the beach chair position, positive end-expiratory pressure, and pneumoperitoneum on respiratory function in morbidly obese patients during anesthesia and paralysis. Anesthesiology 2007; 107(5): 725-32.[http://dx.doi.org/10.1097/01.anes.0000287026.61782.a6] [PMID: 180 73547] -9Defresne AA, Hans GA, Goffin PJ, et al. Recruitment of lung volume during surgery neither affects the postoperative spirometry nor the risk of hypoxaemia after laparoscopic gastric bypass in morbidly obese patients: A randomized controlled study. Br J Anaesth 2014; 113(3): 501-7.[http://dx.doi.org/10.1093/bja/aeu101] [PMID: 2483 3726] ].

CONCLUSION

Preemptive application of recruitment maneuver CPAP 40 cm H2O for 45 seconds followed immediately with PEEP of 15 cm H2O was safe and effective in improving the intraoperative oxygenation and preventing the pneumoperitoneum-induced detrimental respiratory mechanics effects in obese patients undergoing laparoscopic gastric banding.

ETHICS APPROVAL AND CONSENT TO PARTICIPATE HUMAN RIGHTS

All clinical investigations were carried out after obtaining the approval of our institutional ethics and research committee (FMASU R64/2018).

HUMAN AND ANIMAL RIGHTS

No animals were used in the study. All humans research procedures followed were in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2008 (http://www.wma. net/en/20activities/10ethics/10helsinki/).

CONSENT FOR PUBLICATION

Written informed consent was taken from all patients who participated.

AVAILABILITY OF DATA AND MATERIALS

Not applicable.

FUNDING

None.

CONFLICT OF INTEREST

The authors declare no conflict of interest, financial or otherwise.

ACKNOWLEDGEMENTS

Declared none.

REFERENCES

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[2] Tusman G, Böhm SH, Vazquez de Anda GF, Do Campo JL, Lachmann B. ‘Alveolar recruitment strategy’ improves arterial oxygenation during general anaesthesia. Br J Anaesth 1999; 82(1): 8-13.[http://dx.doi.org/10.1093/bja/82.1.8] [PMID: 10325828]
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[12] Chalhoub V, Yazigi A, Sleilaty G, et al. Effect of vital capacity manoeuvres on arterial oxygenation in morbidly obese patients undergoing open bariatric surgery. Eur J Anaesthesiol 2007; 24(3): 283-8.[http://dx.doi.org/10.1017/S0265021506001529] [PMID: 17087847]
[13] Futier E, Constantin JM, Pelosi P, et al. Intraoperative recruitment maneuver reverses detrimental pneumoperitoneum-induced respiratory effects in healthy weight and obese patients undergoing laparoscopy. Anesthesiology 2010; 113(6): 1310-9.[http://dx.doi.org/10.1097/ALN.0b013e3181fc640a] [PMID: 2106 8660]
[14] Maisch S, Reissmann H, Fuellekrug B, et al. Compliance and dead space fraction indicate an optimal level of positive end-expiratory pressure after recruitment in anesthetized patients. Anesth Analg 2008; 106(1): 175-81.[http://dx.doi.org/10.1213/01.ane.0000287684.74505.49] [PMID: 181 65575]
[15] Bohm SH, Thamm OC, von Sandersleben A, et al. Alveolar recruitment strategy and high positive end-expiratory pressure levels do not affect hemodynamics in morbidly obese intravascular volume-loaded patients. Anesth Analg 2009; 109(1): 160-3.[http://dx.doi.org/10.1213/ane.0b013e3181a801a3] [PMID: 19535706]

Endorsements



"Open access will revolutionize 21st century knowledge work and accelerate the diffusion of ideas and evidence that support just in time learning and the evolution of thinking in a number of disciplines."


Daniel Pesut
(Indiana University School of Nursing, USA)

"It is important that students and researchers from all over the world can have easy access to relevant, high-standard and timely scientific information. This is exactly what Open Access Journals provide and this is the reason why I support this endeavor."


Jacques Descotes
(Centre Antipoison-Centre de Pharmacovigilance, France)

"Publishing research articles is the key for future scientific progress. Open Access publishing is therefore of utmost importance for wider dissemination of information, and will help serving the best interest of the scientific community."


Patrice Talaga
(UCB S.A., Belgium)

"Open access journals are a novel concept in the medical literature. They offer accessible information to a wide variety of individuals, including physicians, medical students, clinical investigators, and the general public. They are an outstanding source of medical and scientific information."


Jeffrey M. Weinberg
(St. Luke's-Roosevelt Hospital Center, USA)

"Open access journals are extremely useful for graduate students, investigators and all other interested persons to read important scientific articles and subscribe scientific journals. Indeed, the research articles span a wide range of area and of high quality. This is specially a must for researchers belonging to institutions with limited library facility and funding to subscribe scientific journals."


Debomoy K. Lahiri
(Indiana University School of Medicine, USA)

"Open access journals represent a major break-through in publishing. They provide easy access to the latest research on a wide variety of issues. Relevant and timely articles are made available in a fraction of the time taken by more conventional publishers. Articles are of uniformly high quality and written by the world's leading authorities."


Robert Looney
(Naval Postgraduate School, USA)

"Open access journals have transformed the way scientific data is published and disseminated: particularly, whilst ensuring a high quality standard and transparency in the editorial process, they have increased the access to the scientific literature by those researchers that have limited library support or that are working on small budgets."


Richard Reithinger
(Westat, USA)

"Not only do open access journals greatly improve the access to high quality information for scientists in the developing world, it also provides extra exposure for our papers."


J. Ferwerda
(University of Oxford, UK)

"Open Access 'Chemistry' Journals allow the dissemination of knowledge at your finger tips without paying for the scientific content."


Sean L. Kitson
(Almac Sciences, Northern Ireland)

"In principle, all scientific journals should have open access, as should be science itself. Open access journals are very helpful for students, researchers and the general public including people from institutions which do not have library or cannot afford to subscribe scientific journals. The articles are high standard and cover a wide area."


Hubert Wolterbeek
(Delft University of Technology, The Netherlands)

"The widest possible diffusion of information is critical for the advancement of science. In this perspective, open access journals are instrumental in fostering researches and achievements."


Alessandro Laviano
(Sapienza - University of Rome, Italy)

"Open access journals are very useful for all scientists as they can have quick information in the different fields of science."


Philippe Hernigou
(Paris University, France)

"There are many scientists who can not afford the rather expensive subscriptions to scientific journals. Open access journals offer a good alternative for free access to good quality scientific information."


Fidel Toldrá
(Instituto de Agroquimica y Tecnologia de Alimentos, Spain)

"Open access journals have become a fundamental tool for students, researchers, patients and the general public. Many people from institutions which do not have library or cannot afford to subscribe scientific journals benefit of them on a daily basis. The articles are among the best and cover most scientific areas."


M. Bendandi
(University Clinic of Navarre, Spain)

"These journals provide researchers with a platform for rapid, open access scientific communication. The articles are of high quality and broad scope."


Peter Chiba
(University of Vienna, Austria)

"Open access journals are probably one of the most important contributions to promote and diffuse science worldwide."


Jaime Sampaio
(University of Trás-os-Montes e Alto Douro, Portugal)

"Open access journals make up a new and rather revolutionary way to scientific publication. This option opens several quite interesting possibilities to disseminate openly and freely new knowledge and even to facilitate interpersonal communication among scientists."


Eduardo A. Castro
(INIFTA, Argentina)

"Open access journals are freely available online throughout the world, for you to read, download, copy, distribute, and use. The articles published in the open access journals are high quality and cover a wide range of fields."


Kenji Hashimoto
(Chiba University, Japan)

"Open Access journals offer an innovative and efficient way of publication for academics and professionals in a wide range of disciplines. The papers published are of high quality after rigorous peer review and they are Indexed in: major international databases. I read Open Access journals to keep abreast of the recent development in my field of study."


Daniel Shek
(Chinese University of Hong Kong, Hong Kong)

"It is a modern trend for publishers to establish open access journals. Researchers, faculty members, and students will be greatly benefited by the new journals of Bentham Science Publishers Ltd. in this category."


Jih Ru Hwu
(National Central University, Taiwan)


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