Table 3: Between-group comparison of the lung injury score, icu days, and the need for mechanical ventilation.

Study Groups (Mean ± SD) P-values*
Days A
(saline N)
B
(H saline N)
C
(saline IV)
D
(H saline IV)
A vs B A vs C A vs D B vs C B vs D C vs D Overall
Day 0 3.1 ±0.72 3.2±0.74 3.47±0.63 3.0±0.69 0.094
Day 1 2.93±0.58 3.00±0.53 3.20±0.76 2.55±0.73 0.651 0.156 0.042* 0.276 0.014* 0.003* 0.006*
Day2 2.88±0.91 2.53±1.11 3.07±0.87 2.10±1.07 0.219 0.445 0.007* 0.056 0.161 <0.001 0.004*
Day 3 2.33±1.27 2.1 ±1.10 2.67±0.88 1.80±1.06 0.488 0.267 0.108 0.044* 0.321 0.002* 0.035*
Day 4 1.87±1.15 1.13±1.04 2.40±1.16 1.07±0.94 0.019* 0.104 0.008* <0.001 0.828 <0.001 <0.001
Day 5 1.67±1.08 0.73±1.01 1.53±1.17 1.00±0.89 0.002* 0.655 0.018* 0.011* 0.311 0.072 0.004*
Day 6 1.40±1.15 0.33±0.71 1.27±1.26 0.87±0.71 <0.001 0.699 0.050* <0.001 0.008* 0.165 <0.001
Day 7 0.87±0.90 0.27±0.58 0.73±0.87 0.67±0.69 0.006* 0.571 0.372 0.029* 0.028* 0.784 0.039*
Day 8 0.53±0.73 0.46±0.31 0.67±0.88 0.23±0.35 0.654 0.535 0.064 0.256 0.015* 0.022* 0.013*
Day 9 0.33±0.61 0.27±0.17 0.40±0.72 0.16±0.41 0.082
Day 10 0.27±0.58 0.15±0.11 0.37±0.45 0.11±0.10 0.057
Day 11 0.13±0.51 0.00±0.00 0.00±0.00 0.00±0.00 0.096
Day 12 0.13±0.51 0.00±0.00 0.00±0.00 0.00±0.00 0.096
Day 13 0.00±0.00 0.00±0.00 0.00±0.00 0.00±0.00 1.000
Day 14 0.00±0.00 0.00±0.00 0.00±0.00 0.00±0.00 1.000
ICU Days 9.60±4.10 6.87±2.85 10.13±3.56 7.07±4.21 0.007* 0.620 0.033* <0.001 0.841 0.006* 0.002*
Need for Mechanical Ventilation: Number (%)** A vs B A vs C A vs D B vs C B vs D C vs D
No need 19 (73.1) 10 (38.5) 18 (69.2) 10 (38.5) 0.012* 0.760 0.012* 0.026* 1.000 0.026*
Non-Inv. 5 (19.2) 3 (11.5) 7 (26.9) 6 (23.1) 0.442 0.510 0.734 0.159 0.271 0.749
Inv. 14 (53.8) 7 (26.9) 11 (42.3) 4 (15.4) 0.048* 0.405 0.004* 0.244 0.308 0.032*

Group A (saline N): Standard pharmacotherapy +normal saline 0.9% (5ml) nebulizer /8hr.
Group B(H saline N): Standard pharmacotherapy + hypertonic saline 3% (5ml) nebulizer /8hr
Group C(saline IV):Standard pharmacotherapy + normal saline 0.9% (500ml) intravenous /24hr
Group D(H saline IV Standard pharmacotherapy + hypertonic saline 3% (500ml) intravenous /24hr
Abbreviations: SD: standard deviation. .
* ANOVA with Least Significant Difference test was used for between-group comparisons of means and x2 test for comparison of proportions.
Significance level was at P-value ≤0.05** Percentages were taken out of 26 (the group total).
background shade (D50%):mean reduction of score to half of baseline values