Fig. (2) A)- Graphical representation of the average histology scores of the mice. This graph shows the averages and error bars for the two mouse strains FVB control mice and mdr1a -/- gene targeted mutant mice. B)- Cross sectional images of colonic tissue from an FVB control mouse (histological injury score of 0) and an mdr1a -/- gene targeted mutant mouse (inflammatory bowel disease model with histological injury score of 25). The FVB mouse colonic tissue contains crypts (example indicated by black arrow), which are columns of white goblet cells and are normal structures of a healthy gut, with no cells between them. However the mdr1a -/- gene targeted mutant mouse colonic tissue contains very few crypts with no visible goblet cells inside. Almost all of the structures of the mucus layer are destroyed and the crypt cavities begin to fill with pink pus cells. The purple dots located between the cavities are inflammatory cells.