Table 2: IC50, KI, Log P Values and Inhibition Type of Alkyl Gallate against Soybean Lipoxygenase-1

Gallates Tested µM Log P Inhibition Type
IC50a KI
C1 (2) >200 - 0.69 -
C3 (3) 82.6 39.9 1.27 Competitive
C6 (4) 8.7 4.40 2.76 Competitive
C8 (5) 1.3 0.54 3.60 Competitive
C9 (6) 0.6 0.21 4.01 Mixed
C10 (7) 0.15 -b 4.43 Mixed
C11 (8) 0.12 - 4.85 -
C12 (9) 0.07 - 5.27 Slow binding
C14 (10) 0.06 - 6.10 Slow binding
NDGA 0.19 - - -

a Assay condition of [E]: 0.141 µg/mL; [S]: 18 µM; Buffer: 0.1M Tris-HCl (pH8.0).
bNot tested.