Fig. (4) Suppression of TNF-α (A) and IL-6 (B) production by AMC in mice treated with collagen. AMC at 0 (●), 3 (▲), or 30 mg/kg (■) was orally administered to immunized mice after priming. Mock-immunized mice (○) were administered 5% gum arabic. Sera were prepared from 4 to 7 mice in each group on days 27, 31, and 41 after priming. The concentrations of TNF-α (A) and IL-6 (B) in sera are expressed as the mean±SEM. *p<0.05 vs. mockimmunized mice by Student’s t-test.