Table 1: Effects of AMC in Collagen-Induced Arthritis in DBA/1 Micea

Compound Dose Incidence Mean Weight Mean Number of Anti-Collagen
(mg/kg) of 4 Paws Degenerated Joints IgG (A490)
27 day 31 day 41 day
Mock-immunized mice 0/5 0.40±0.01 0.0±0.0 0.002±0.002 0.002±0.002 0.003±0.001
Collagen-immunized mice
AMC 0 7/7 0.46±0.02 14.0±3.3 0.500±0.084 0.569±0.086 0.794±0.063
AMC 30 2/7b 0.40±0.01b 2.4±0.8c 0.361±0.081 0.397±0.055 0.632±0.047

a AMC at 0 and 30 mg/kg was orally administered to collagen-immunized DBA1 mice after priming. Incidence, the mean weight of paws and the mean number of degenerated joints of 5 or 7 mice in a group were determined on day 35 after priming.
Sera were prepared on days 27, 31, and 41, and the amount of anti-collagen type II antibody in sera was determined by ELISA.
Values except Incidence are mean±SEM.
b p<0.05 vs. AMC at 0 mg/kg by Fischer’s exact test or Student’s t-test.
c p<0.005 vs. AMC at 0 mg/kg by Student’s t-test.