a AMC at 0 and 30 mg/kg was orally administered to collagen-immunized DBA1 mice after priming. Incidence, the mean weight of paws and the mean number of degenerated joints
of 5 or 7 mice in a group were determined on day 35 after priming.
Sera were prepared on days 27, 31, and 41, and the amount of anti-collagen type II antibody in sera was determined by ELISA.
Values except Incidence are mean±SEM.
b p<0.05 vs. AMC at 0 mg/kg by Fischer’s exact test or Student’s t-test.
c p<0.005 vs. AMC at 0 mg/kg by Student’s t-test.