Fig. (3) Modulatory effect of the antioxidant compounds on PQ-induced locomotor deficits measured by negative geotaxis assay. Flies exposed to multiple dose of PQ showed a significant reduction in the climbing activity in males (A) and females (B). Treatment with antioxidants (4-Hydroxyisophthalic acid-DHA-I, Nicotinamide-NA, Ellagic Acid-EA, Quercetin-Que) ameliorated the PQ-induced locomotor deficits in both sexes. Values are mean±S.E. (n=6; 10 flies per replicate) and bars denoted by identical lowercase alphabets (a–c) indicate no significant difference, whereas, values denoted by different alphabets indicate a statistically significant difference (p<0.05).