Fig. (4) Protective action of the antioxidant compounds on PQ-induced oxidative stress. Treatment with multiple-dose of PQ showed significant induction of ROS in males (A) and females (B) with the concomitant increase of LPO level in males (C) and females (D). Treatment with antioxidant compounds (4-Hydroxyisophthalic acid-DHA-I, Nicotinamide-NA, Ellagic Acid-EA, Quercetin-Que) markedly reduced the level of ROS and LPO in both sexes. Values are mean±S.E. and bars denoted by identical lowercase alphabets (a–c) indicate no significant difference, whereas, values denoted by different alphabets indicate a statistically significant difference (p<0.05).