Fig. (5) PQ-induced GSH depletion and protective effect of the antioxidant compounds. Both males (A) and females (B) showed a significant decrease in GSH content when exposed to multiple dose of PQ. Treatment with antioxidant compounds (4-Hydroxyisophthalic acid-DHA-I, Nicotinamide-NA, Ellagic Acid-EA, Quercetin-Que) protected against GSH depletion. Values are mean±S.E. and bars denoted by identical lowercase alphabets (a–c) indicate no significant difference, whereas, values denoted by different alphabets indicate a statistically significant difference (p<0.05).