Table 1: Metal Ion Binding (MIB) Server [³³] results showing the different binding affinities and the different interacting residues per cofactor-bound S100β protein with the cofactors represented as spherical balls.

Cofactor-Bond S100β	Binding Residues	Binding Scores	3D Model of the Best Binding Mode
Ca 2+ - S100β	62D, 64D, 66D, 68E, 73E	2.891
	62D, 64D, 65G, 66D, 68E, 69C, 73E	2.766
Mg2+ - S100β	62D, 64D, 66D, 68E	2.031
	62D, 64D, 66D, 68E, 73E	1.944
Zn2+ - S100β	86H, 87E	1.538
	55D, 59E	1.480