Fig. (15) Change of normalized blood perfusion (w/w_37C) in normal porcine kidney tissue during heating as a function of vascular stasis predicted using the 1^st order kinetic model: Blood perfusion increases initially when the predicted vascular stasis is less than ~ 10% followed by a gradual decrease and eventually complete stasis, indicating the first order model is insufficient in predicting the change of blood perfusion in response to heating in normal tissue. It is reported that the initial increase in blood perfusion from the baseline value is absent in heating tumor tissue in vivo. Figure reprinted and redrawn from reference [38] with permission from Informa.