Table 1: Lipids and Proteins Targeted to Lipid Rafts and Caveolae

Lipid Rafts Caveolae Ref.
Lipid components: Lipid components:
Cholesterol Cholesterol [90, 115, 209, 210, 211, 212]
Sphingomyelin Sphingomyelin
Glyco-sphingolipid Glyco-sphingolipid
Phosphatidylinositol 4,5-bisphosphate Phosphatidylinositol 4,5-bisphosphate
Ganglioside GM1 Ganglioside GM1
Ganglioside GM3
Structural proteins: Signalling proteins:
Flotillin-1 and –2 Flotillin-1 and –2 [9, 10, 11, 24, 213]
Caveolin-1, -2 and –3
Signalling proteins: Signalling proteins:
H-Ras H-Ras [32, 42, 48, 49, 56, 57, 115, 160, 214]
Gi, Go, Gβ Gq
Src kinases Src kinases
Syk kinase eNOS
Grb2, Erk2 Phosphatidylinositol 3-kinase
Shc Phospholipase C
Receptors: Receptors:
PDGF receptor PDGF receptor [56, 96, 115, 128, 136, 137, 215]
EGF receptor EGF receptor
IGF-1 receptor IGF-1 receptor
TrkA, TrkB TrkA
CD36
GPI-Anchored proteins:
e.g. CD59 uPAR [216, 217]

EGF: epidermal growth factor; eNOS: endothelial nitric oxide synthase; Erk: extracellular signal-regulated kinase; IGF: insulin-like growth factor; PDGF: platelet-derived growth factor; Trk: tyrosine kinase receptor; uPAR: urokinase-type plasminogen activator receptor.