Table 3: Lipid and inflammatory parameters stratified by ART experience.
| Variable |
Mean (SD) |
P-value |
| N=152 |
ART naïve
n=28 |
ART experienced
n=124 |
- |
| Lipids |
- |
- |
- |
| LDL-C (mmol/L) |
2.3 (0.76) |
2.5 (0.98) |
0.315 |
| TC (mmol/L) |
3.8 (0.8) |
4.6 (1.1) |
0.0005** |
| HDL-C (mmol/L) |
0.9 (0.3) |
1.3 (0.4) |
0.0003** |
| TC/HDL-C ratio |
4.1 (1.3) |
3.9 (1.2) |
0.404 |
| - |
Median (IR) |
- |
| Inflammatory Markers |
- |
- |
| IL-10 (pg/ml) |
3.5 (3.1-3.3) |
3.8 (3.2-4.9) |
0.020** |
| TNF-α (pg/ml) |
15.9 (14.9 -17.7) |
11.6 (10.2-15.7) |
<0.0001** |
| TNF-α/IL-10 ratio |
4.5 (3.7-4.9) |
3.3 (2.0-4.1) |
<0.0001** |
| hs CRP (mg/dL) N*=65
|
2 (1-3.9) |
3.8 (2.2-8.9) |
0.417 |
N, total number of study participants; N*, fewer participants; n, number of study participants per sub-group; SD, standard deviation; IR, interquartile range; TC, total cholesterol; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; IL-10, interleukin 10; TNF-α. tumour necrosis factor-alpha; hsCRP, highly sensitive C reactive protein; Starred P-values** designate significant P-value <0.05, where β= 0.2 and α=0.05 at 95% CI