Table 6: Comparison of median levels of inflammatory markers by ART type.

Marker ART-naive TDF/
NVP/
3TC
TDF/
EFV/
3TC
STV or ZDV
+NVP/3TC
2nd Line P-value
- n=27 (17.8%) n=91 (59.9%) n=17 (11.2%) n=6 (3.9%) n=11 (7.2%) -
TNF-α (pg/ml) 159.1(149.9- 176.5) 117.1 (103.4- 154.7) Median (IR)
111.7 (105.6- 172)
114.1(31.1- 147.2) 97.5 (47.1- 162.5) 0.029**
IL-10 (pg/ml) 34.9(30.6- 40) 36.6 (31.8- 47.5) 41.6(36.5- 59.5) 39.1(27.8-49.6) 43.4 (32.4-56.9) 0.001**
TNF-α/IL-10 4.53(3.70- 4.90) 3.38 (2.27- 4.18) 2.89(2.08-3.09) 3.81 (0.63- 4.54) 2.95(0.71- 3.54) 0.002**
- n=8(5.26%) n=42(27.63%) n=7(4.61%) n=3(1.97%) n=5(3.29%) -
hs CRP(mg/dl) 2(1- 3.95) 3.8 (1.4- 8.2) 3.4 (2.9-13.9) 6.5 (2.2-8.9) 14.3 (3.8-14.5) 0.481

N, number of participants per sub-group; IL-10, interleukin 10; TNF-α, tumour necrosis factor-alpha; hsCRP, highly sensitive C reactive protein, Starred P-values** designate significant P <0.01, calculated for five comparative ART groups, where β = 0.2 and α=0.05 at 95% CI