| HIV Infection Stage (CDC, 1993) | Controls | ||||
|---|---|---|---|---|---|
|
Comparison Group 1 (HIV-infected subjects under HAART) (n=125) |
Comparison Group 2 (healthy donors) (n=140) |
||||
|
Group I (A1, A2) (n= 240) |
Group II (B2, B2) (n=130) |
Group III (C1, C2) (n=60) |
|||
| Age (years) | 34±5.8 | 35±5.7 | 35±5.8 | 34±4.4 | 36±5.1 |
| Male (n) | 240 | 130 | 60 | 125 | 140 |
| Receiving HAART (n) | 0 | 0 | 0 | 125 | - |
| Duration of HIV (months) | 31±12.3 | 52±12.2 | 84±13.7 | 68±11.5 | - |
| HIV risk factor (IDU) (n) | 240 | 130 | 60 | 125 | - |
|
HIV/HCV co-infection (%/n) |
93/223 | 92/120 | 94/56 | 93/116 | - |
| Body mass index (BMI) (kg/m2) | 22.75±2.57 | 22.99±3.32 | 23.32±2.11 | 23.84±2.17 | 22.62±2.43 |
| Viral charge ± (s.e.) (copies/ml) | 109.300± 10.300* |
186.700± 21.400* |
321.100± 44.670* |
0.500±0.45* | - |
| CD4 (cells/µl) | 488.7± 212.1● |
332.5± 238.5*● |
251.2± 165.8*● |
424.4± 203.8*″ |
1253.7± 230.3●″ |
| CD8 (cells/µl) | 1030.2± 477.4● |
1088.7± 541.8*● |
1197.7± 383.5*● |
987.3± 487.4*″ |
712.4± 303.1●″ |
| CD4/CD8 ratio | 0.45±0.18● | 0.31±0.21● | 0.22±0.20*● | 0.38±0.19*″ | 1.75±0.14●″ |
| ALT (IU/ml) | 69.5 ± 45.1*● | 67.2±44.9*● | 102.3±50.2● | 131.8±54.0*″ | 25.0±15.1●″ |
| AST (IU/ml) | 64.0 ± 56.4*● | 75.6±36.3*● | 94.5±62.4● | 102.3±53.7*″ | 24.0±15.0●″ |
| Bilirubin (µmol/l) | 9.7±4.3 | 10.3±3.9 | 10.1±4.1 | 10.2±4.9 | 7.1±3.2 |
| Alkaline phosphatase (ALP) (IU/l) | 101.3±83.2● | 93.5±46.3● | 98.1±57.6● | 85.7±44.3″ | 55.3±36.1●″ |
| Lactate dehydrogenase (LDH) (IU/l) | 338.3±148.1 | 335.7±125.5 | 394.1±198.2● | 352.4±154.8 | 288.7±81.4● |
| Creatinine (µmol/l) | 89.3±36.1 | 88.2±28.3 | 85.2±49.1 | 89.3±38.0 | 90.5±33.2 |
| Gamma-glutamyltrans-ferase (GGT) (IU/l) | 78.2±53.5● | 92.2±68.5● | 129.1±84.7● | 89.4±67.5″ | 27.7±18.7●″ |
| Urea (mmol/l) | 4.77±3.15 | 4.56±2.81 | 4.68±3.12 | 4.69±2.78 | 4.31±3.12 |
|
Serum protein (g/l) |
75.3±5.8 | 76.2±6.2 | 75.8±5.3 | 75.4±6.0 | 76.8±5.4 |
| Glucose (mmol/l) | 5.4±0.82 | 5.5±0.78 | 5.7±0.75 | 5.3±0.80 | 5.3±0.90 |
|
Total cholesterol (mmol/l) |
5.40±0.53* | 5.72±0.48* | 5.76±0.51* | 6.82±0.60*″ | 5.35±0.38″ |