Fig. (3) Comparison of the primary and tridimensional structures of the GGQ domain common to the eukaryotic eL42 proteins and the translation termination factors. (A), overlaid structures of the GGQ domain (the M domain) of human eRF1 (Acc. N. P62495) colored green and eL42 (colored brown) modeled in [23]. The methylated GGQ motif is highlightened (red). (B), conserved region in the GGQ domain of the eukaryotic eL42 proteins and the translation termination factors. Multiple sequence alignment of the region encompassing the GGQ motif common to the class-1 translation termination factors and the rps of the eukaryotic eL42 family was generated with the program ClustalX. The amino acid residues that are conserved in majority in either group are colored red. The bottom line labels residues as either strictly conserved (*) or highly conserved (:).