Table 1: The treatments used in growth assays to detect the effects of formulation constituents on the growth rate of both MCF-7 cells and TamR cells. Cells were seeded at a density of 1.5 million cells per plate on day 0. On day 1 cells were counted and then treated. Additional counts were at days 4, 7 and 9 and treatments replenished on day 4.

Cell Line	Treatments	Concentrations
MCF-7	DMSO	0.1µL mL-1
	4-hydroxytamoxifen	1 x 10-7 M
	PD98059	25 µM
	LY294002	5 µM
	LY294002 + PD98059 + 4-hydroxytamoxifen	As in single treatments
	Fish oil	1 µL mL-1
	Fish oil + LY294002 + PD98059 + 4-hydroxytamoxifen	As in single treatments
	E2	1 x 10-9 M
TamR	DMSO	0.1 µL mL-1
	PD98059	25 µM
	LY294002	5 µM
	LY294002 + PD98059	As in single treatments
	Fish oil	1 µL mL-1
	Fish oil + LY294002 + PD98059	As in single treatments
	E2	1 x 10-9 M
	Faslodex	1 x 10-7 M