The Clock Genes Are Involved in The Deterioration of Atopic Dermatitis after Day-and-Night Reversed Physical Stress in NC/Nga Mice

Fig. (3) Effect of day-and-night reversal stress on skin symptoms and AD scores, and histological analysis of the skin. A) Skin symptoms and AD scores after the two-week treadmill treatment. B) A histological analysis of skin tissue actions after the treadmill treatment. C) The mice ran on a treadmill for 12 h at nighttime (8:00 pm-8:00 am). Skin symptoms and AD scores after the two-week treadmill treatment. –AD: SPF NC/Nga mice, +AD: conventional NC/Nga mouse, AD: Atopic dermatitis. The values are presented at the mean ± standard deviations, derived from 6 animals.*, P<0.05. Scale bar = 100 μm.