Table 1: Human and veterinary clinical application and potential toxic effects of TCs.

TETRACYCLINE KIND	HUMAN CLINICAL PURPOSE	VETERINARY CLINICAL PURPOSE	POTENTIAL TOXIC EFFECTS
Doxycycline	Toxoplasma gondii infection [1], respiratory infections [19, 129], malaria [131], acne [27], rosacea [29, 33, 34], cutaneous sarcoidosis [47], Sweet’s syndrome [53], a1-antitrypsin deficiency panniculitis [55], leukemia [65, 67], ocular adnexal lymphomas [70], ocular adnexal MALT lymphoma [71], lymphangioleiomyomatosis [72], abdominal aortic aneurysms [73], Chlamydia pneumonia infection with aneurysms [74], acute myocardial infarction [75], periodontal disease [78, 79], long-standing type-2 diabetes and untreated chronic periodontitis [81]	filarial nematodes [21, 130], Leishmania major infection (Leishmaniasis) [131], disease prevention, morbidity and mortality reduction and growth promotion [87, 88]	DNA synthesis reduction [112], polymorphonuclear leukocyte oxygen consumption reduction [114], environmental, manure, soil, surface waters, groundwater and wastewater pollution [119, 123-125]
Achromycin	malaria [19, 132]
Oxytetracycline	Entamoeba histolytica infection (Amebiasis) [133, 134], Trichomonas vaginalis infection (Trichomoniasis) and Leishmania major infection (Leishmaniasis) [135], Giardia lamblia infection (Giardiasis) [133, 135], food intolerances induction [115]	Giardia lamblia infection (Giardiasis) [133], disease prevention, morbidity and mortality reduction and growth promotion [87, 88, 127], adverse food reactions induction [15, 101]	pro-apoptotic effect [100, 106], pro-inflammatory effect [105, 107, 109], genotoxic effect [110], neutrophils and mononuclear cells modulation [103], oxidative stress and immunosuppression induction [104], toxicity against catalase [108], villous epithelium damage [111], T lymphoid cells division inhibition [113], cytotoxic [116], environmental, manure, soil, surface waters, groundwater pollution [119, 123, 124, 128]
Tetracycline	Giardia lamblia infection (Giardiasis) [133, 135], filarial nematodes [136], acne [24], rosacea [28], bullous pemphigoid [35-37, 40-42], suppurative hidradenitis [52], chronic pityriasis lichenoides [56], metastatic prostate cancer [66]	filarial nematodes [21], Giardia lamblia infection (Giardiasis) [133], Leishmania major infection (Leishmaniasis) [131], digital dermatitis [93]	environmental, manure, soil, and surface waters, groundwater and wastewater pollution [120, 123-124-125]
Thiatetracycline	Giardia lamblia infection (Giardiasis) [134]	Giardia lamblia infection (Giardiasis) [134]
Minocycline	Toxoplasma gondii infection [1], acne [26], cicatricial pemphigoid [38, 39], cutaneous sarcoidosis [44-46], pyoderma gangrenosum [51], rheumatoid arthritis [58-60], scleroderma [61, 62], acute ischemic stroke [76], fragile X syndrome [82], acute encephalitis syndrome [83], schizophrenia [86]	filarial nematodes [137]	groundwater and surface water pollution [124]
COL-3	Kaposi’s sarcoma [49, 50], refractory metastatic cancer [68, 69]
CMT-1, -3, and -5	periodontal disease [78]
Demethylchlortetracycline			polymorphonuclear leukocyte oxygen consumption reduction [114]
Chlortetracycline		growth promotion [88, 89, 127]	manure, soil, surface waters and groundwater pollution [123, 124, 128]
Meclocycline			manure, soil, surface waters and groundwater pollution [123, 124]