Fig. (11) Schematic of the binding sites of antibiotics and reactive small-molecule inhibitors on bacterial 70S or human 80S ribosomes. (A) and (B) 70S or 80S ribosomes in the absence of inhibitors. (C) and (D) 70S or 80S ribosomes in the presence of azithromycin or erythromycin. (E) and (F) 70S or 80S ribosomes in the presence of tetracycline. (G) and (H) 70S or 80S ribosomes in the presence of both azithromycin (or erythromycin) and tetracycline. (I) and (J) 70S or 80S ribosomes in the presence of reactive substrate analogues referred to as R.