Table 1: Summary of Structural Properties of 2S Allergens

Allergen name Species (common name) Allergen designation Epitope mapping Cross-reactivity Sequence accession number (ExPASy) Mr of mature protein (kDa) Subunits number 3D Structure Accession Number (RCSB/PDB) Ref.
Ana o 3 Anacardium occidentale (Cashew nut) Major 8 (linear) Not known Q8H2B8 12.6 2 Not determined [58, 103]
Ara h 2 Arachis hypogaea(Peanut) Major 10 (linear) Other 2S albumins from peanut Q6PSU2 17.3 Not determined Not determined [35, 36, 54, 104-107]
Ara h 6 Arachis hypogaea(Peanut) Minor Not known Other 2S albumins from peanut Q647G9 14.5 Not determined 1W2Q [40, 99]
Ara h 7 Arachis hypogaea(Peanut) Minor Not known Other 2S albumins from peanut Q9SQH1 (Precursor) 15.8 Not determined Not determined [99]
Ber e 1 Bertholletia excelsa (Brazil nut) Major 3 (T-cell epitopes) Helix III-hypervariable region-helix IV conformation is immunodominant 2S albumins from walnut, cottonseed, sunflower, castor bean P04403 12.2 2 Not determined [18, 19, 34, 45, 56, 57]
Bra j 1 Brassica juncea (Oriental mustard) Major 1 (linear) 2S albumins from genus Brassica P80207 14.6 2 Not determined [51, 98, 108]
BnIa/BnIb Brassica napus (Rapeseed) Minor Not known 2S albumins from genus Brassica P24565 12.5 2 1PNB (global fold) 1SM7 (precursor form) [21, 39, 43, 109]
Bra n 1 (BnIII) Brassica napus (Rapeseed) Major Not known 2S albumins from genus Brassica P80208 13.9 2 Not determined [21, 30, 98, 110]
Bra n 2S albumin Brassica nigra (Black mustard) Major Not known Not known Q42491 (Precursor) Not determined Not determined Not determined [111]
Bra r 1 Brassica rapa (Turnip) Major Not known Not known Q42473 (Precursor) 9.5-14.5 2 Not determined [93, 111]
Car i 1 Carya illinoinensis (Pecan) Not known Not known Q84XA9 (Precursor) 15.4 2 Not determined [46, 112]
Cic a 2S Albumin Cicer arietinum (Chickpea) Major Not known Not known Not determined 20.0 2 Not determined [113, 114]
Fag e 10kD Fagopyrum esculentum (Buckwheat) Major Not known Not known Q8W3Y9 (Precursor) 10.0 Not determined Not determined [115, 116]
Fag e 16kD Fagopyrum esculentum (Buckwheat) Major Not known Not known Q2PS07 (Precursor) 14.6 Not determined Not determined [63, 117-119]
Gly m 2S albumin Glycine max (Soya) Minor Not known Not known P19594 14.0 2 Not determined [37, 66, 120-122]
CS-1A Gossypium herbaceum (Arabian cotton) Not known Not known Not determined 15.0 Not determined Not determined [123-124]
Mat5-D Gossypium hirsutum (Upland cotton) Not known Not known Q39787 (Precursor) 12.1 2 Not determined [124-125]
SFA-8 Helianthus annuus (Sunflower seed) Not known 2S albumins from mustard P23110 12.1 1 1S6D [16, 32, 44, 100, 126-128]
Jug n 1 Juglans nigra (Black walnut) Not known Not known Q7Y1C2 (Precursor) 19.0 Not determined Not determined [129, 130]
Jug r 1 Juglans regia (English walnut) Major 1 (linear) Not known P93198 (Partial sequence) 14.0 2 Not determined [52, 131]
Pru du 2S Albumin Prunus dulcis (Almond) Major Not known Not known P82944 (Partial sequence) 12.0 Not determined Not determined [92]
Ric c 1 Ricinus communis (Castor bean) Major Not known Not known P01089 11.3 2 Not determined [132-134]
Ric c 3 Ricinus communis (Castor bean) Major Not known Not known P01089 12.0 2 1PSY [24, 42, 133, 134]
Ses i 1 Sesamum indicum (Sesame) Major Not known 2S albumin from poppy seed Q9AUD1 12.1 2 Not determined [25, 101, 135]
Ses i 2 Sesamum indicum (Sesame) Major 9 (linear) 2S albumin from poppy seed Q9XHP1 12.5 2 Not determined [53, 101, 135-137]
Sin a 1 Sinapis alba (Yellow mustard) Major 1 (linear) 2S albumins from genus Brassica P15322 14.2 2 Not determined [50, 98, 138, 139]