Fig. (7) Time-dependent effects of CPA on the activity of distinct
NOS isoforms of platelet. Activity measurements were performed
as described in Materials and Methodology and assessed by RNS
accumulation in vitro after long-term incubation of platelet isolated
from blood of control rats (1) and CPA-treated rats sacrificed 9
days (2) and 18 days (3) after final treatment. Stimulatory effect of
exogenous arginine and NOS cofactors on both iNOS and cNOS of
platelet observed for conrol rats was restored in CPA-treated rats in
18 days pt. Values are means ± S.E.M. P<0.05 compared with control.