Molecules Acting on CB1 Receptor and their Effects on Morphine Withdrawal In Vitro

Table 3: ED50 and 95% C.L. Values of CB1Rs Agonist WIN 55,212-2, CP 55,940 or A-F (1x10^-8-5x10^-8-1x10^-7 M) on Morphine Withdrawal. Each CB1Rs Agonist was Administered 10 min Before (A) or After (B) Morphine

Compounds	Morphine Withdrawal (A)	Morphine Withdrawal (B)
WIN 55,212-2	2.1x10^-8 M (1.5x10^-9-2.4x10^-7)	3.1x10^-8 M (5.5x10^-9-3.1x10^-7).
CP 55,940	2,5x10^-8 M (3.5x10^-9-4.3x10^-7)	3.5x10^-8 M (2.7x10^-9-4.3x10^-7).
CB1R-A	3.5x10^-8 M (2.5x10^-9-1.9x10^-8)	3.7x10^-8 M (4.5x10^-9-2.3x10^-7)
CB1R-B	2.7x10^-8 M (3.4x10^-9-1.7x10^-8)	2.9x10^-8 M (3.5x10^-9-1.7x10^-7)
CB1R-C	3.1x10^-8 M (2.9x10^-9-4.1x10^-8)	3.5x10^-8 M (2.5x10^-9-4.3x10^-7)
CB1R-D	2.9x10^-8 M (1.3x10^-9-3.3x10^-8)	2.2x10^-8 M (1.5x10^-9-3.3x10^-7)
CB1R-E	2.4x10^-8 M (3.3x10^-9-1.9x10^-8)	3.2x10^-8 M (4.5x10^-9-2.3x10^-7)
CB1R-F	2.5x10^-8 M (3.3x10^-9-1.6x10^-8)	3.6x10^-8 M (4.5x10^-9-2.3x10^-7)