Table 3: ED50 and 95% C.L. Values of CB1Rs Agonist WIN 55,212-2, CP 55,940 or A-F (1x10-8-5x10-8-1x10-7 M) on Morphine Withdrawal. Each CB1Rs Agonist was Administered 10 min Before (A) or After (B) Morphine

Compounds Morphine Withdrawal (A) Morphine Withdrawal (B)
WIN 55,212-2 2.1x10-8 M (1.5x10-9-2.4x10-7) 3.1x10-8 M (5.5x10-9-3.1x10-7).
CP 55,940 2,5x10-8 M (3.5x10-9-4.3x10-7) 3.5x10-8 M (2.7x10-9-4.3x10-7).
CB1R-A 3.5x10-8 M (2.5x10-9-1.9x10-8) 3.7x10-8 M (4.5x10-9-2.3x10-7)
CB1R-B 2.7x10-8 M (3.4x10-9-1.7x10-8) 2.9x10-8 M (3.5x10-9-1.7x10-7)
CB1R-C 3.1x10-8 M (2.9x10-9-4.1x10-8) 3.5x10-8 M (2.5x10-9-4.3x10-7)
CB1R-D 2.9x10-8 M (1.3x10-9-3.3x10-8) 2.2x10-8 M (1.5x10-9-3.3x10-7)
CB1R-E 2.4x10-8 M (3.3x10-9-1.9x10-8) 3.2x10-8 M (4.5x10-9-2.3x10-7)
CB1R-F 2.5x10-8 M (3.3x10-9-1.6x10-8) 3.6x10-8 M (4.5x10-9-2.3x10-7)