Fig. (11) IDE as a therapeutic approach for AD. Aβ is degraded by ApoE, IDE and α2M. Aβ binds to IDE, which allows its degradation inside the CNS. The remaining Aβ binds ApoE and α2M that pass through the BBB via LRP. A portion of soluble Aβ can also efflux from the LRP to re-enter the brain via RAGE. The peripheral ApoE-Aβ and α2M-Aβ complexes enter the liver and kidney, where they are degraded.