Potential Therapeutic Effects of Vitamin E and C on Placental Oxidative Stress Induced by Nicotine: An In Vitro Evidence

Table 1: The Effect of Nicotine Alone (20-100 pg/ml) and in Presence of Vitamin C, Vitamin E and NAC (5pM) on MDA Level in the Placental Villi

Nicotine Administration (6h)	MDA Levels Nicotine Alone (% of control)	MDA Levels Nicotine+Vitamin C (% of control)	MDA Levels Nicotine+Vitamin E (% of control)	MDA Levels Nicotine+NAC (% of control)
Control Nicotine 0 pg/ml	100	100	100	100
Nicotine 20 pg/ml	113±31	114±21	105±10	101±11
Nicotine 50 pg/ml	130±12^*	103±12^§§	105±11^§§	102±10^§§
Nicotine 100 pg/ml	207±26^**	110±21^§§	107±10^§§	101±11^§§

Results are expressed as mean+S.E.M..

^* P<0.05

^** P<00.1 was accepted as indicative of significant difference between groups (nicotine vs control, n=5).

^§§ P<00.1 (nicotine+vitamins vs nicotine alone).