Table 5: Terms Associated with the High Dose-responsive Gene List as Determined Through the Ingenuity Pathway Analysis (IPA) Bioinformatic Tools. The “Ratio” Heading Represents How Many Genes were Differentially Expressed in a Canonical Pathway Divided by the Number of Genes in the Pathway. The “Molecules” Heading Shows which Genes are Differentially Expressed within the Pathway

Ingenuity Canonical Pathways	-log(p-value)	Ratio	Molecules
Mitotic Roles of Polo-Like Kinase	4.26	6.15E-02	KIF23,CDC20,CCNB2,CCNB1
Cyclins and Cell Cycle Regulation	2.62	3.37E-02	CCNA2,CCNB2,CCNB1
Cell Cycle Control of Chromosomal Replication	2.43	6.67E-02	MCM6,MCM2
Cell Cycle: G2/M DNA Damage Checkpoint Regulation	2.02	4.08E-02	CCNB2,CCNB1
ATM Signaling	1.88	3.7E-02	CCNB2,CCNB1
p53 Signaling	1.41	2.11E-02	TP53INP1,BIRC5