Table 5: Terms Associated with the High Dose-responsive Gene List as Determined Through the Ingenuity Pathway Analysis (IPA) Bioinformatic Tools. The “Ratio” Heading Represents How Many Genes were Differentially Expressed in a Canonical Pathway Divided by the Number of Genes in the Pathway. The “Molecules” Heading Shows which Genes are Differentially Expressed within the Pathway

Ingenuity Canonical Pathways -log(p-value) Ratio Molecules
Mitotic Roles of Polo-Like Kinase 4.26 6.15E-02 KIF23,CDC20,CCNB2,CCNB1
Cyclins and Cell Cycle Regulation 2.62 3.37E-02 CCNA2,CCNB2,CCNB1
Cell Cycle Control of Chromosomal Replication 2.43 6.67E-02 MCM6,MCM2
Cell Cycle: G2/M DNA Damage Checkpoint Regulation 2.02 4.08E-02 CCNB2,CCNB1
ATM Signaling 1.88 3.7E-02 CCNB2,CCNB1
p53 Signaling 1.41 2.11E-02 TP53INP1,BIRC5