Table 1: miRNAs responsive at all doses from array profiling. Statistically significant differentially expressed miRNA with corresponding p-values and fold changes (FC) which were found to respond at all doses of α-particle radiation tested (0.5, 1.0, and 1.5 Gy) and were harvested 24 hours post-exposure. Statistical cut-off at p ≤ .05, FC≥|1.5| with n = 5 biological replicates

Cell-Type miRNA 0.5 Gy FC p-Value 1.0 Gy FC p-Value 1.5 Gy FC p-Value
A549 hsa-miR-486-5p 1.94 0.00 2.57 0.00 2.91 0.00
hsa-miR-187 1.54 0.00 1.81 0.00 2.00 0.00
hsa-miR-25* -1.69 0.02 -1.69 0.02 -1.67 0.02
hsa-miR-92a-1* -1.84 0.00 -1.93 0.00 -2.11 0.00
hsa-miR-424* -2.21 0.00 -1.79 0.01 -1.87 0.00
hsa-miR-16-1* -1.61 0.01 -1.56 0.01 -1.63 0.00
hsa-miR-23a* -1.73 0.01 -1.54 0.03 -1.66 0.01
HFL-1 hsa-miR-663 2.87 0.01 2.42 0.02 2.19 0.01
hsa-miR-491-5p 1.47 0.03 1.64 0.01 1.61 0.01
hsa-miR-560:9.1 2.47 0.00 2.48 0.00 2.17 0.01
hsa-miR-675 2.75 0.00 2.34 0.05 1.79 0.05
hsa-miR-1228* 1.53 0.01 1.54 0.01 1.58 0.01
THP-1 hsa-miR-708 2.03 0.02 2.16 0.02 2.51 0.00

* an miRNA expressed at low levels relative to the miRNA in the opposite arm of a hairpin