Table 2: Factors Leading to HDL Heterogeneity

CETP and PLTP	Generates lipid-free/lipid-poor ApoA-I and remodels spherical HDL into large and small particles.
LCAT	Discoidal HDL→spherical HDL, Generates lipid-free/lipid-poor ApoA-I
HL	Large TG rich-HDL→small spherical -HDL Generates lipid-free/lipid-poor ApoA-I.
EL	Small spherical -HDL→smaller HDL particles. Does not generate lipid-free/lipid-poor ApoA-I.
SR-B 1	Spherical -HDL→smaller HDL particles. Does not generate lipid-free/lipid-poor ApoA-I.