Table 2: Topranked polymorphisms based on consensus prediction of functional impact.

No. SNP PolyPhen2 Prediction PolyPhen2 Probability SIFT
Prediction
SIFT
Score
phdsnp
Prediction
phdsnp
Reliability
1 G185V Prob. Damaging 1 Damaging 1 Disease 8
2 R593C benign 0.392 Damaging 1 Disease 6
3 E566K Prob. Damaging 1 Damaging 0.88 Disease 6
4 Q1107P Prob. Damaging 0.962 tolerated 0.19 Disease 6
5 A999T Poss. Damaging 0.465 tolerated 1 Neutral 7