Receptor |
Ligand |
Interacting Residues |
Wildtype |
Drug1 |
Leu244,Tyr247,Arg286,Ile289,Lys290,Ile293,Ala823,Lys826 |
Wildtype |
Drug2 |
Gly141,Ile144,His145,Arg148,Val179,Ser180,Asn183,Asp886,Leu890,Leu924,Pro927,Tyr928,Ser931,Lys934 |
Wildtype |
Drug3 |
Gly141,Ile144,His145,Arg148,Val179,Ser180,Asn183,Asp886,Leu890,Leu924,Pro927,Tyr928,Ser931,Lys934 |
Wildtype |
Drug4 |
Met701,Asn704,Leu705,Trp708,Ile829,Arg832,Leu833 |
G185V |
Drug1 |
Thr422,Leu554,Gln556,Ala557,Thr558,Gln570,Leu573,Asp574,Arg577,Val584,Thr591,Val592,Asn594,Ala595 |
G185V |
Drug2 |
Ile199,Phe303,Tyr307,Asn721,Leu724,Gln725,Ser766,Gln838,Met986,Ala987,Gln990,Val991,Phe994 |
G185V |
Drug3 |
Ile199,Phe303,Tyr307,Asn721,Leu724,Gln725,Ser766,Gln838,Ala987,Gln990,Val991,Phe994 |
G185V |
Drug4 |
Lys291,Ala292,Asn296,Gln773,Phe777,Gly778,Glu782,Lys826,Ser831,Phe994,Ala995,Pro996 |
R593C |
Drug1 |
Leu244,Tyr247,Lys285,Arg286,Ile289,Lys290,Ile293,Thr785,Lys826 |
R593C |
Drug2 |
Thr627,Met628,Gln629,Thr630,Leu688,Phe804,Pro807,Lys808,Asn809,Thr810,Thr811 |
R593C |
Drug3 |
Gln132,Val133,Trp136,Ile190,Glu875,Leu879,Phe938,Thr941,Phe942 |
R593C |
Drug4 |
Gln132,Val133,Trp136,Ile190,Glu875,Leu879,Phe938,Gly939,Thr941,Phe942 |
E566K |
Drug1 |
Leu244,Tyr247,Lys285,Arg286,Ile289,Lys290,Ile293,Thr785,Lys826 |
E566K |
Drug2 |
Gln132,Val133,Trp136,Cys137,Gly187,Ile190,Glu875,Leu879,Phe938,Thr941,Phe942 |
E566K |
Drug3 |
Ile293,Phe777,Gly778,Gly781,Ala823,Gln824,Lys826,Gly827,Ile829,Gly830,Phe994,Ala995,Pro996 |
E566K |
Drug4 |
Ser831,Ala834,Val835,Gln838,Gln990,Val991,Ser992,Ser993,Phe994,Ala995,Pro996,Asp997,Tyr998 |
Q1107P |
Drug1 |
Tyr247,Glu282,Arg286,Lys290,Gly781,Glu782,Thr785,Arg789,Ala823,Gln824,Lys826 |
Q1107P |
Drug2 |
Asp689,Glu690,Ser691,Ile692,Lys808,Asn809,Ala813,Leu814,Thr816,Arg817,His1007,Met1010,Ile1011 |
Q1107P |
Drug3 |
Val133,Trp136,Cys137,Glu875,Leu879,Lys934,Phe938,Thr941,Phe942 |
Q1107P |
Drug4 |
Ser831,Ala834,Val835,Gln838,Gln990,Val991,Ser992,Ser993,Phe994,Ala995,Pro996,Asp997,Tyr998 |
A999T |
Drug1 |
Leu244,Tyr247,Glu282,Arg286,Ile289,Lys290,Ile293,Thr785,Arg789,Ala823,Lys826 |
A999T |
Drug2 |
Ala259,Ala260,Ile261,Arg262,Thr630,Leu688,Phe804,Pro807,Lys808,Asn809,Thr810,Thr811,Leu814 |
A999T |
Drug3 |
Ser831,Ala834,Val835,Gln838,Gln990,Val991,Ser993,Phe994,Ala995,Pro996,Asp997,Tyr998 |
A999T |
Drug4 |
Ser831,Ala834,Val835,Gln838,Gln990,Val991,Ser992,Ser993,Phe994,Ala995,Pro996,Asp997,Tyr998 |