Table 3: Pharmacology of ergot and non-ergot derivatives of dopamine agonists.

Ergoline Derivatives					Non-Ergoline Derivatives
Name of Derivatives	Bromocriptine	Cabergoline	Pergolide	Lisuride	Apomorphine	Piribedil	Pramipexole	Ropinirole	Rotigotine
Trade Name (s)	Parlodel and Cycloset	Cabaser and Dostinex	Permax and Prascend	Dopergin, Proclacam and Revanil	Apokyn, Ixense, Spontane and Uprima	Trivastal, Pronoran, Trastal and Trivastan	Mirapex and Mirapex ER	Requip and Requip XL	Neupro
Half-life (t½)	12-14 hours	63-69 hours	27 hours	2 hours	30-60 minutes	20 hours	8-12 hours	6 hours	3 hour
Peak Plasma Time	58 minutes	2-3 hours	2-3 hours	40 min	10-60 min	1 hour	IR-2 hour, ER-6 hour	IR -1-2 hour, ER 6-10 hour	15-18 hour
Highest binding affinity	D2 receptors	D2 receptors	D2 receptors	D2 receptor	D2 receptor	D2 and D3 receptors	D3 receptor	D2 and D3 receptors	D3 receptor
Chemical formula	C32H40BrN5O5	C26H37N5O2	C19H26N2S	C20H26N4O	C17H17NO2	C16H18N4O2	C10H17N3S	C16H24N2O	C19H25NOS
Protein Binding (%)	90-96%	40-42%	90%	15%	50%	-	15%	40% bound to plasma proteins	92%
Metabolism	Gastrointestinal tract and liver	Hepatic	Hepatic	-	Hepatic	-	Hepatic	Hepatic	Hepatic
Route of Administration	oral, vaginal, intravenous	Oral	Oral	Oral	Subcutaneous	-	Oral	Oral	Transdermal
Route of Elimination	Liver and Kidney	Urine, Fecal	Kidney	-	-	-	Urine	Urine	Urine, Fecal