Table 5: The diagnostic validity and the optimal cut-off values of Talin-1 gene expression and AFP as markers for HCC.

Test Cut-off value Sensitivity% Specificity% PPV% NPV% AUC% P-value
Talin-1 gene(2-∆∆CT) 9.5 93.3 80 100 93.7 85.7 0.000*
AFP ng/ml 13.1 60 69.9 100 71.4 65.4 0.018*

AFP: Alpha-fetoprotein;PPV=positive predictive value;NPV=negative predictive value; AUC=area under curve;2-∆∆CT=relative gene quantification (CT=cycle threshold);*:Values statistically significant (at P< 0.05).