Table 5: The diagnostic validity and the optimal cut-off values of Talin-1 gene expression and AFP as markers for HCC.
Test |
Cut-off value |
Sensitivity% |
Specificity% |
PPV% |
NPV% |
AUC% |
P-value |
Talin-1 gene(2-∆∆CT) |
9.5 |
93.3 |
80 |
100 |
93.7 |
85.7 |
0.000* |
AFP ng/ml |
13.1 |
60 |
69.9 |
100 |
71.4 |
65.4 |
0.018* |
AFP: Alpha-fetoprotein;PPV=positive predictive value;NPV=negative predictive value; AUC=area under curve;2-∆∆CT=relative gene quantification (CT=cycle threshold);*:Values statistically significant (at P< 0.05).