Fig. (1) Schematic picture showing internalization of Al adjuvants into a cell through an early phagosome containing Al-adjuvant aggregate(s) and due to encapsulation of the adjuvant also a saturated solution of A^l3+ ions. Upon entrance into the cell, Al-particles and dissolved A^l3+ ions can be expected to influence; 1) the endosomal pathway 2) mitochondrial function and activity 3) cellular stress functions 4) protein synthesis and folding 5) nuclear structure and function.