The Open Biotechnology Journal




ISSN: 1874-0707 ― Volume 13, 2019
EDITORIAL

Current Trends in Toxin Analysis of Agricultural Products: Improving the Food Safety with the Help of Biotechnologies



Tzonka Godjevargova1, *
1 University “Prof. d-r Asen Zlatarov”, Burgas, Bulgaria


Article Information


Identifiers and Pagination:

Year: 2019
Volume: 13
Issue: Suppl-1, M1
First Page: 111
Last Page: 112
Publisher Id: TOBIOTJ-13-111
DOI: 10.2174/187407070190130111

Article History:

Electronic publication date: 15/11/2019
Collection year: 2019

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© 2019 Godjevargova et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the University “Prof. d-r Asen Zlatarov”, Burgas, Bulgaria; E-mail: godjevargova@yahoo.com





Food safety has become an extremely important problem for modern society. With increasing pollution of agricultural products with various toxic compounds, the need for techno- logical control and consumer health protection has increased [1Velusamy V, Arshak K, Korostynska O, Oliwa K, Adley C. An overview of foodborne pathogen detection: In the perspective of biosensors. Biotechnol Adv 2010; 28(2): 232-54.
[http://dx.doi.org/10.1016/j.biotechadv.2009.12.004] [PMID: 2000 6978]
]. Therefore, new methods for sensitive and rapid on-site detection of toxic contaminants in food and agricultural products are required. The aim of this thematic issue is to carry out the detection of various toxic contaminants in food and agricultural products, and also the development of new sensitive methods for their detection. Pathogenic micro-organisms such as Aspergillus flavus, Fusarium langsethia, and Staphylococcus aureus and their toxic metabolite compounds – aflatoxins, T-2 toxins, and enterotoxins, respec- tively, are present in agricultural products and are dangerous for human health [2Hennekinne JA, De Buyser ML, Dragacci S. Staphylococcus aureus and its food poisoning toxins: Characterization and outbreak investigation. FEMS Microbiol Rev 2012; 36(4): 815-36.
[http://dx.doi.org/10.1111/j.1574-6976.2011.00311.x] [PMID: 2209 1892]
]. Furthermore, pathogenic microorganisms cause mastitis in cows. During the onset of mastitis, neutrophils get activated, attracted and attempt to kill the invading pathogens [3Becheva Z, Gabrovska K, Godjevargova T. Immunofluorescence microscope assay of neutrophils and somatic cells in bovine milk. Food Agric Immunol 2017; 1-6.
[http://dx.doi.org/10.1080/09540105.2017.1332012]
]. Studying the role of neutrophils in the infection and its subsequent effect on some of the milk quality parameters is a very important task. Also, organophosphorus pesticides play an important role in agriculture, but they are very toxic compounds and they need constant monitoring [4Bhadekar R, Pote S, Tale V, et al. Developments in analytical methods for detection of pesticides in environmental samples. Am J Anal Chem 2011; 2: 1-15.
[http://dx.doi.org/10.4236/ajac.2011.228118]
]. The necessity of wide screening control of food and agriculture contamination is due to the widespread distribution and the significant and multiple toxic effects of these toxic compounds. The high toxicity of these toxins requires accurate and reliable detection methods for safety food, agricultural products and water. It is necessary to develop rapid and sensitive assays for the determination of low concentrations of these toxic compounds. Therefore, different new sensitive methods for the determination of the mentioned toxins are presented in this thematic issue. All the proposed assays are based on an immunoreaction antibody-antigen that is highly specific and sensitive [5Yang JY, Xu ZL. Immunochemical techniques for multianalyte analysis of chemical residues in food and the environment: A review. Trends in Analytical Chemistry 2017; 88: 25e40..]. A rapid and sensitive fluorescent immunoassay based on Magnetic Nanoparticles (MNPs) with a polyclonal and monoclonal antibody for deter-mination of enterotoxin A and an MNP-based enzyme-linked immunosorbent assay (ELISA) for simultaneous determina-tion of two pesticides in milk have been developed. The use of MNPs led to the development of integrated methods that provide a better assay sensitivity (pg/ml), rapid analysis and simple washing procedures [6Cao H, He J, Deng L, et al. Fabrication of cyclodextrin-functionalized superparamagnetic Fe3O4/amino-silane core-shell nanoparticles via layer-by-layer method. Appl Surf Sci 2009; 255: 7974-80.
[http://dx.doi.org/10.1016/j.apsusc.2009.04.199]
]. In the thematic issue, schemes for immuno- chromatographic analysis of aflatoxin B1 and T2 toxin are proposed. There, the separation of the stage of specific interaction and the stage of introduction of the labeled conjugate allows reducing the concentration of specific antibodies and increasing the sensitivity of the analysis. It is shown that indirect labeling in the analysis of mycotoxins increased the sensitivity up to 20 times compared with the traditional scheme systems for aflatoxin B1 and T2 toxin. The QCM immunosensors for the detection of aflatoxin B1 in low concentrations are also proposed. The advantage of QCMs over other endpoint measuring tools is their ability to make real-time measurements. The study of various toxic contaminants in food and agricultural products and the development of new sensitive methods for their detection will lead to quality assurance of food and its safety.

The guest editor firmly believes that the collection of papers in this special issue will be of interest and useful to the research community.

CONFLICT OF INTREST

The authors declare no conflict of interest, financial or otherwise.

ACKNOWLEDGEMENTS

I wish to thank all the authors for their contribution and especially to all the reviewers for their critical insight and timely reviews of the manuscripts, without which this thematic issue was not possible.


REFERENCES

[1] Velusamy V, Arshak K, Korostynska O, Oliwa K, Adley C. An overview of foodborne pathogen detection: In the perspective of biosensors. Biotechnol Adv 2010; 28(2): 232-54.
[http://dx.doi.org/10.1016/j.biotechadv.2009.12.004] [PMID: 2000 6978]
[2] Hennekinne JA, De Buyser ML, Dragacci S. Staphylococcus aureus and its food poisoning toxins: Characterization and outbreak investigation. FEMS Microbiol Rev 2012; 36(4): 815-36.
[http://dx.doi.org/10.1111/j.1574-6976.2011.00311.x] [PMID: 2209 1892]
[3] Becheva Z, Gabrovska K, Godjevargova T. Immunofluorescence microscope assay of neutrophils and somatic cells in bovine milk. Food Agric Immunol 2017; 1-6.
[http://dx.doi.org/10.1080/09540105.2017.1332012]
[4] Bhadekar R, Pote S, Tale V, et al. Developments in analytical methods for detection of pesticides in environmental samples. Am J Anal Chem 2011; 2: 1-15.
[http://dx.doi.org/10.4236/ajac.2011.228118]
[5] Yang JY, Xu ZL. Immunochemical techniques for multianalyte analysis of chemical residues in food and the environment: A review. Trends in Analytical Chemistry 2017; 88: 25e40..
[6] Cao H, He J, Deng L, et al. Fabrication of cyclodextrin-functionalized superparamagnetic Fe3O4/amino-silane core-shell nanoparticles via layer-by-layer method. Appl Surf Sci 2009; 255: 7974-80.
[http://dx.doi.org/10.1016/j.apsusc.2009.04.199]

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