Fig. (5) Proposed models for casoplatelin and fibrinogen interaction. The five models (labeled Model 1 to Model 5) of casoplatelin obtained from Rosetta are shown in their post-docked orientation. The peptides are shown in stick representation, where three models are shown to bind to the helical region of Fibrinogen and two models are shown to bind to the “head” part of the protein. The model explains the mode of interaction with the C chain of fibrinogen and thus possibly prevents the formation of thrombotic clots.