Fig. (1) At 20 hours after exposure to E variant of encephalomyocarditis (EMC-E) virus, 18% of neuroblastoma (NB) cells show the initial alterations in proliferation and dilation of the endoplasmic reticulum (ER) and of Golgi complex (GC) and vesicular formation (VF) with single membrane bound vacuoles from the Golgi and ER. At 24 hours, 20% of the cells show a marked loss of the ribosomes in addition to the changes of ER, GC and VF. At 32 hours, 60% of the cells reveal cytopathic effect (CPE) with severe degeneration consisting of a loss of the ribosomes, the alterations of ER, GC, VF and mitochondria (M). After 48 hours, 100% CPA is observed.