Table 1: Independent variables and their levels in the experimental design.

Independent Variable Symbols Unit Code Levels
- - - -1.68 (-α) -1 0 1 1.68 (+α)
Time A min 39.55 60 90 120 140.45
Temperature B ᵒC 49.77 60 75 90 100.23
Solvent concentration C % 36.36 50 70 90 103.64