Interpreting the Mechanism of APOE (p.Leu167del) Mutation in the Incidence of Familial Hypercholesterolemia; An In-silico Approach

Table 1: Calculated binding energy of both wild-type and mutated protein complexes as predicted by the hex doc server.

Interacting Protein Complex		Total Docking Energy (kJ/mol)	Differences in Docking Energy	Level of Binding Affinity
Receptor Protein	Ligand Protein	Total Docking Energy (kJ/mol)	Differences in Docking Energy	Level of Binding Affinity
LDLR	APOE wild type	-643.33	-	-
LDLR	APOE p.Leu167del	-472.3	171.03	↑↑