Table 1: Comparison of biochemical data between the Longevity and the Early Death Group.

– Early Death (EAD) Group p Longevity (LON) Group p p
LON vs EAD
– FD1 (n=34) FD2
(n=31) 		(FD1-FD2) P (n=28) FL1 (n=28) FL2 (n=28) P-FL1,
FL1-FL2,
P-FL2 		(FL1-FD1,
FL2-FD2)
Age (years) 58.5
(51.7-66.3)		 33.0
(26-38)		 <0.001 93
(90-96)		 63.5
(58.3-66.7)		 31.0
(26.3-39.0)		 <0.001
<0.001
<0.001 		0.02
0.72
Gender M 16 (47)
18 (53)		 15 (48)
16 (52)		 0.79 11 (39)
17 (61)		 11 (39)
17 (61)		 14 (50)
14 (50)		 1.00
0.42
0.42		 0.54
F 0.90
BMI (kg/m2) 27
(25-30)		 23
(21-26)		 0.005 23
(22-27)		 27
(24-30)		 23
(21-26)		 0.009
0.003
0.62		 0.96
0.58
TC (mg/dL) 195
(160-238)		 183
(135-209)		 0.07 185
(144-214)		 192
(149-226)		 173
(155-206)		 0.36
0.19
0.78		 0.56
0.81
TGs (mg/dL) 101
(72-151)		 53
(39-72)		 0.001 77
(62-129)		 75
(54-130)		 44
(31-68)		 0.70
0.002
0.001 		0.23
0.68
HDL-cholesterol (mg/dL) 51
(33-58)		 51
(41-61)		 0.23 44
(35-52)		 45
(36-71)		 55
(50-61)		 0.28
0.28
0.02 		0.30
0.21
LDL- cholesterol (mg/dL) 119
(87-151)		 111
(72-146)		 0.21 116
(85-1150)		 119
(81-154)		 101
(94-124)		 0.74
0.34
0.51		 0.59
0.92
UA (mg/dL) 4.6
(3-6)		 4.1
(3-5)		 0.02 4.7
(4-6)		 4.4
(3-6)		 4.1
(3-5)		 0.23
0.48
0.06		 0.28
0.62
GL (mg/dL) 101
(97-114)		 90
(83-96)		 <0.001 103
(89-123)		 98
(88-113)		 88
(82-97)		 0.44
0.04
0.002 		0.74
0.55
CETP
(μg/mL) 		1.9
(1.7-2.4)		 1.7
(1.5-2.3)		 0.78 1.97
(1.7-2.3)		 2.2
(1.9-2.5)		 2.2
(1.9-2.7)		 0.03
0.93
0.03 		0.22
0.13
ACE (ng/mL) 145
(105-168)		 126
(110-154)		 0.32 140
(113-158)		 157
(131-169)		 136
(127-170)		 0.14
0.55
0.26		 0.29
0.10
IGF-1 (ng/mL) 72
(65-93)		 123
(92-188)		 <0.001 57
(36-74)		 83
(67-107)		 123
(101-160)		 <0.001
<0.001
<0.001 		0.19
0.82
ADIPOQ (μg/mL) 6
(3-9)		 6
(4-11)		 0.65 15
(9-21)		 7
(4-11)		 8
(6-133)		 0.001
0.69
0.004 		0.40
0.12
Statin use, yes 21 (62) 2 (6) <0.001 9 (32) 12 (43) 0 (0) 0.40
-
-		 0.18
-

LON: Longevity, EAD: Early Death, P: older individuals, FL1: 1st generation of longevity group, FL2: 2nd generation of longevity group, FD1: 1st generation of EAD Group, FD2: 2nd generation of EAD Group. M: Male, F: Female, BMI: Body mass index, HDL: High density lipoprotein, LDL: Low density lipoprotein, UA: Uric acid, GL: Glucose, CETP: Cholesterol ester transfer protein, ACE: Angiotensin converting enzyme, IGF-1: Insulin-like growth factor-1. ADIPOQ: Adiponectin. Data are presented as median (25-75 percentile) or n (%). Bold means statistical significance with p < 0.05. *The Bonferroni correction was used for the comparison (by one-way ANOVA) of TC, TGs, HDL-C, LDL-C, UA, GL, CETP, ACE, IGF-1 and ADIPOQ between EAD vs LON groups; p = 0.0025