Table 2a: Associations between gene polymorphisms and their related proteins.
| –
|
Early Death (EAD) Group |
Longevity (LON) Group |
| –
|
FD1 |
FD2 |
P |
FL1 |
FL2 |
| –
|
b-value |
p |
b-value |
p |
b-value |
p |
b-value |
p |
b-value |
p |
CETP levels- CETP TaqIB genotype
(B1B1 vs B2B2)
|
-0.22 |
0.28 |
-0.36 |
0.05 |
-0.16 |
0.45 |
-0.021 |
0.89 |
-0.45 |
0.03 |
CETP levels- CETP I405V genotype
(II vs VV)
|
-0.22 |
0.51 |
-0.31 |
0.26 |
-0.012 |
0.95 |
-0.046 |
0.87 |
-0.26 |
0.36 |
ACE levels- ACE I/D genotype
(II vs DD)
|
23.28 |
0.009 |
21.96 |
0.007 |
6.45 |
0.44 |
41.33 |
0.02 |
25.11 |
<0.001 |
IGF1levels- IGFBP3 genotype
(AA vs CC)
|
-5.37 |
0.18 |
-0.011 |
0.99 |
0.89 |
0.87 |
7.23 |
0.25 |
-10.44 |
0.55 |
AdipoQ levels- ADIPOQ+45T>G genotype
(TT vs GG)
|
-1326.5 |
0.43 |
-590.85 |
0.64 |
800.7 |
0.73 |
- |
- |
- |
- |
LON: Longevity, EAD: Early Death, P: older individuals, FL1: 1st generation of longevity group, FL2: 2nd generation of longevity group, FD1: 1st generation of EAD Group, FD2: 2nd generation of EAD Group, IGF-1: Insulin-like growth factor-1, Cholesterol ester transfer protein (CETP) TaqIB (rs708272. genotypes: B1B1, B1B2, B2B2), CETP I405V (rs5882, genotypes II, IV, VV), Angiotensin converting enzyme (ACE, rs1799752, genotype II, ID, DD), IGFBP3: IGF-binding protein 3 (IGFBP3, rs2854744, genotype AA, AC, CC) and Adiponectin (ADIPOQ, rs2241766, genotype GG, GT, TT), b-value: regression coefficient, bold highlights statistical significance with p < 0.05.