Table 2b: Multivariate regression analysis of gene polymorphisms and their related proteins after adjustment for age and gender.
| –
|
Early Death (EAD) Group |
Longevity (LON) Group |
| –
|
FD1 |
FD2 |
P |
FL1 |
FL2 |
| –
|
b-value |
p |
b-value |
p |
b-value |
p |
b-value |
p-Value |
b-value |
p |
CETP levels- CETPTaqIB genotype
(B1B1vs B2B2)
|
-0.31 |
0.14 |
-0.34 |
0.10 |
-0.34 |
0.004 |
0.12 |
0.45 |
-0.62 |
0.007 |
CETP levels- CETP I405V genotype
(II vs VV)
|
-0.03 |
0.27 |
-0.58 |
0.06 |
0.15 |
0.52 |
-0.11 |
0.71 |
-0.009 |
0.97 |
ACE levels- ACE I/D genotype
(II vs DD)
|
27.59 |
0.007 |
18.55 |
0.03 |
7.89 |
0.43 |
54.22 |
0.02 |
26.62 |
0.001 |
IGF1levels- IGFBP3 genotype
(AA vs CC)
|
-3.98 |
0.23 |
-15.36 |
0.21 |
-2.94 |
0.62 |
6.49 |
0.32 |
-3.37 |
0.85 |
AdipoQ levels- ADIPOQ+45T>G genotype
(TT vs GG)
|
-392.1 |
0.81 |
-447.68 |
0.65 |
937.5 |
0.73 |
- |
- |
- |
- |
LON: Longevity, EAD: Early Death, P: older individuals, FL1: 1st generation of longevity group, FL2: 2nd generation of longevity group, FD1: 1st generation of EAD Group, FD2: 2nd generation of EAD Group. IGF-1: Insulin-like growth factor-1, Cholesterol ester transfer protein (CETP) TaqIB (rs708272. genotypes: B1B1, B1B2, B2B2), CETP I405V (rs5882, genotypes II, IV, VV), Angiotensin converting enzyme (ACE, rs1799752, genotype II, ID, DD), IGFBP3: IGF-binding protein 3 (IGFBP3, rs2854744, genotype AA, AC, CC) and Adiponectin (ADIPOQ, rs2241766, genotype GG, GT, TT), b-value: regression coefficient, bold highlights statistical significance with p < 0.05.