-
|
Overall |
No Deterioration
|
Deterioration |
p-value |
n=59 |
n=41 |
n=16 |
-
|
Demographic & Co-morbidities |
Age at diagnosis (years), mean (SD) |
29.5 (6.8) |
29.7 (7.5) |
28.8 (4.5) |
0.659 |
Black, n (%) |
17 (28.8) |
13 (31.7) |
4 (25.0) |
0.619 |
Hypertension, n (%) |
21 (35.6) |
19 (44.2) |
2 (12.5) |
0.024 |
Preeclampsia, n (%) |
13 (22.0) |
10(23.3) |
3 (18.8) |
0.710 |
Diabetes, n (%) |
11 (18.6) |
10 (23.3) |
1 (6.3) |
0.136 |
Thyroid disease, n (%) |
5 (8.5) |
3 (7.0) |
2 (12.5) |
0.498 |
Autoimmune disorders, n (%) |
3 (5.1) |
1 (2.3) |
2 (12.5) |
0.114 |
Follow-up (months), mean (SD) |
76.0 (7.8) |
73.0 (8.8) |
84.1 (16.5) |
0.530 |
Medications |
ACEi/ARB, n (%) |
53 (89.8) |
38 (88.4) |
15 (93.8) |
0.543 |
Beta-blocker, n (%) |
53 (89.8) |
38 (88.4) |
15 (93.8) |
0.543 |
Spironolactone, n (%) |
41 (69.5) |
32 (74.4) |
9 (56.3) |
0.178 |
Digoxin, n (%) |
33 (55.9) |
24 (55.8) |
9 (56.3) |
0.976 |
Diuretic, n (%) |
54 (91.5) |
38 (88.4) |
16 (100) |
0.915 |
Bromocriptine, n (%) |
2 (3.4) |
2 (4.6) |
0 (0) |
0.380 |
Ejection Fraction |
EF at diagnosis, mean (SD) |
20.8 (11.0) |
20.7 (10.2) |
21.1 (13.0) |
0.904 |
EF at 12 months, mean (SD) |
38.8 (23.0) |
40.4 (23.3) |
28.8 (20.5) |
0.284 |
Final EF, mean (SD) |
37.7 (21.9) |
41.6 (22.1) |
25.2 (18.0) |
0.010 |
Peak EF, mean (SD) |
44.1 (20.2) |
43.1 (22.3) |
44.3 (16.3) |
0.853 |
Recovered EF ≥55%, n (%) |
22 (37.3) |
20 (46.5) |
2 (12.5) |
0.016 |
Major Adverse Outcomes |
Deceased, n (%) |
12 (20.3) |
6 (14.0) |
6 (37.5) |
0.046 |
Left ventricular assist device, n (%) |
10 (17.2) |
5 (11.6) |
5 (33.3) |
0.055 |
Cardiac Transplantation, n (%) |
5 (8.8) |
2 (4.8) |
3 (20.0) |
0.073 |
Inotrope-dependent, n (%) |
9 (15.5) |
5 (11.9) |
4 (25.0) |
0.218 |
Overall MACE, n (%) |
19 (32.2) |
10 (23.3) |
9 (56.3) |
0.016 |
Abbreviations: ACEi = Angiotensin-Converting Enzyme Inhibitors; ARB = Angiotensin Receptor Blocker; MACE = Major Adverse Cardiac Events (including death, left ventricular assist device, cardiac transplantation, or inotrope-dependence); EF = Ejection Fraction; SD = Standard Deviation